dc.contributor.advisor | Carlo Giovanni Traverso. | en_US |
dc.contributor.author | Arrick, Graham(Graham Philip) | en_US |
dc.contributor.other | Massachusetts Institute of Technology. Department of Mechanical Engineering. | en_US |
dc.date.accessioned | 2021-05-14T16:29:56Z | |
dc.date.available | 2021-05-14T16:29:56Z | |
dc.date.copyright | 2020 | en_US |
dc.date.issued | 2020 | en_US |
dc.identifier.uri | https://hdl.handle.net/1721.1/130613 | |
dc.description | Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020 | en_US |
dc.description | Cataloged from the official PDF version of thesis. | en_US |
dc.description | Includes bibliographical references (pages 59-62). | en_US |
dc.description.abstract | Biologics are a class of therapeutic substances composed of large and complex "macromolecules." Examples include vaccines, insulin, monoclonal antibodies, and allergens. However, a practical limitation of these molecules is that they are easily degraded by digestive processes and, as a result, are not generally considered effective for oral dosing. Therefore, these life-saving drugs are typically delivered via intravenous, intramuscular or subcutaneous injection. Oral administration, however, yields some of the highest patient adoption and adherence rates, and is often critical in determining a drug's efficacy. Herein lies the goal of this research: to make it possible to successfully deliver a broad set of biologics by mouth. To that end, needleless delivery, or jetting, has been identified as a promising approach. This work describes mechanistic modeling of jets, an empirical evaluation of jet interaction with gastrointestinal tissues, a millimeter-scale jetting device capable of autonomous drug delivery, and in-vivo studies in which the tested devices elicit substantial drops in blood glucose levels via the delivery of insulin across the gastric mucosa. | en_US |
dc.description.statementofresponsibility | by Graham Arrick. | en_US |
dc.format.extent | 69 pages | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Massachusetts Institute of Technology | en_US |
dc.rights | MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided. | en_US |
dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | en_US |
dc.subject | Mechanical Engineering. | en_US |
dc.title | Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract | en_US |
dc.type | Thesis | en_US |
dc.description.degree | S.M. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
dc.identifier.oclc | 1249942789 | en_US |
dc.description.collection | S.M. Massachusetts Institute of Technology, Department of Mechanical Engineering | en_US |
dspace.imported | 2021-05-14T16:29:56Z | en_US |
mit.thesis.degree | Master | en_US |
mit.thesis.department | MechE | en_US |