MEMS-VCSEL swept-source optical coherence tomography for multi-MHz endoscopic structural and angiographic imaging
Author(s)Zhang, Jason,S.M.Massachusetts Institute of Technology.
Microelectromechanical-system, vertical-cavity surface-emitting laser swept-source optical coherence tomography for multi-MHz endoscopic structural and angiographic imaging
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.
James G. Fujimoto.
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Swept-source optical coherence tomography (SS-OCT) enables volumetric imaging of subsurface structure, but applications requiring wide fields of view, rapid imaging, and higher resolutions have been challenging because of the need for multi-MHz A-scan rates. Until now, achieving multi-MHz A-scan rates has been limited to Fourier-domain mode-locked lasers or stretched-pulse lasers. We describe a microelectromechanical-system, vertical-cavity surface-emitting laser (MEMS-VCSEL) for SS-OCT at A-scan rates of 2.4 and 3.0 MHz using a dual-channel acquisition system. Dual-channel operation enables simultaneous acquisition of Mach-Zehnder interferometer (MZI) fringes for sweep-to-sweep calibration and resampling, overcoming inherent optical clock limitations in state-of-the-art digitizers. We demonstrate structural OCT and OCT angiography (OCTA) imaging of the swine gastrointestinal tract using a suite of endoscopic devices, including a 3.2 mm diameter micromotor catheter, a 12 mm diameter tethered capsule, and a 12 mm diameter wide-field OCTA probe. MEMS-VCSELs promise to enable ultrahigh-speed SS-OCT with a scalable, low cost, and manufacturable technology, suitable for a diverse range of imaging applications.
Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, February, 2021Cataloged from the official PDF version of thesis.Includes bibliographical references (pages 67-72).
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology
Electrical Engineering and Computer Science.