Browsing Doctoral Theses by Title
Now showing items 46-65 of 22282
-
A Bioinspired Approach to Engineer the Seed Microenvironment
(Massachusetts Institute of Technology, 2022-02)Bioinspired by the tardigrade and bombyx mori, we engineer the seed microenvironment to encapsulate, preserve and deliver Rhizobium tropici. Scientific discoveries in agriculture and sustainability are at the crossroads ... -
A Biomaterial-based Stem Cell Therapy for Retinal Regeneration
(Massachusetts Institute of Technology, 2022-02)Retinal diseases such as age-related macular degeneration and diabetic retinopathy are the leading cause of blindness worldwide with prevalence and resulting costs projected to increase. There are few available treatments, ... -
A blood exchange method to study circulation kinetics of tumor cells in the blood
(Massachusetts Institute of Technology, 2023-06)Blood is an essential compartment for tumor cell trafficking. In solid epithelial-derived tumors, blood serves as the major vehicle for metastasis, whose principal cell is the circulating tumor cell (CTC). These cells ... -
A broadened HLA ligandome uncovers new immunotherapy targets for pancreatic cancer + A prime editor mouse to model a broad spectrum of somatic mutations
(Massachusetts Institute of Technology, 2023-02)Pancreatic cancer is a lethal malignancy recalcitrant to immune checkpoint blockade and other immunotherapies. A subset of tumors is computationally predicted to harbor potentially immunogenic peptides for MHC class I ... -
A Cavity-Coupled Rydberg Atom Array Platform for Quantum Computing
(Massachusetts Institute of Technology, 2023-06)Neutral atom systems have long been the test bed for complex quantum physics. Recently, much of the focus in quantum research has shifted from fundamental science to applications in quantum computation. Although several ... -
A Closer Look at Classical Measurement, an Algorithm for Deliberation in Rodents, and a Conjecture on Intertemporal Choice
(Massachusetts Institute of Technology, 2022-05)In this three-part thesis, Part I is an examination of the measurement process in classical Hamiltonian mechanics. This part is concerned with the tradeoff that exists, when measuring any observable of a system, between ... -
A Coherent Categorification of the Asymptotic Affine Hecke Algebra
(Massachusetts Institute of Technology, 2023-06)Kazhdan–Lusztig categorified the affine Hecke algebra H in terms of equivariant coherent sheaves on the Steinberg variety. Recently, Ben-Zvi–Chen–Helm–Nadler have applied the formalism of categorical traces to construct a ... -
A Common Cellular Response to Broad Splicing Perturbations
(Massachusetts Institute of Technology, 2024-05)Cells are constantly experiencing stress that arises from external environmental factors or internal dysfunction. Despite this, cells are remarkably robust, and possess organized cellular response pathways to adapt to ... -
A computational framework for emotion understanding
(Massachusetts Institute of Technology, 2022-09)The organizing principle of this thesis is that human emotion understanding reflects a model-based solution to a large class of ill-posed inverse problems. To interpret someone's expression, or predict how that person would ... -
A Continuous-Time Pipeline ADC with Reduced Sensitivity to Clock Jitter
(Massachusetts Institute of Technology, 2023-06)With the advent of the fifth-generation (5G) standard for cellular networks, direct RF receivers are becoming popular in applications such as cellular base stations. Such systems require analog-to-digital converters (ADC) ... -
A Conversational Agent for Dynamic Procedural Interactions
(Massachusetts Institute of Technology, 2023-06)How-To questions (e.g., “How do I cook rice?”, “How do I write a check?”, or “How do I send pictures to my family from my iPhone?”) are some of the most common questions asked of search engines and presumably of conversational ... -
A Data-Based Perspective on Model Reliability
(Massachusetts Institute of Technology, 2024-02)Neural networks can fail to generalize to real world data — particularly on subpopulations that might have been mislabelled, corrupted, or underrepresented during training. In such settings, the set of features that a model ... -
A Defense of Impermissivism
(Massachusetts Institute of Technology, 2022-09)This dissertation is a defense of Impermissivism, which is the thesis that there is never more than one rational response to a single body of evidence. Permissivism is the view that there is sometimes more than one ... -
A deterministic model for wear of piston ring and liner and a machine learning-based model for engine oil emissions
(Massachusetts Institute of Technology, 2021-09)Nowadays, more constraints are required for design of internal combustion engines, to meet the energy saving and the emissions standards in the new era. Engine emissions and engine durability are two of the most important ... -
A Dual Perspective on Computational Complexity
(Massachusetts Institute of Technology, 2022-09)One central aim of theoretical computer science is to understand the limits of computation. On the one hand, algorithms give upper bounds on the resources required for a computation. They are intuitive, well-studied, and ... -
A Dynamic Primitives Hypothesis: a Descriptive Model of Human Physical Interaction
(Massachusetts Institute of Technology, 2023-02)Physical interaction is a key aspect of activities of daily living. These tasks require simultaneous regulation of both force and motion. For example, even a task as simple as opening a door presents a challenge to the ... -
A First Complete Approach to Address Model Error in Computational Turbulent Heat Transfer
(Massachusetts Institute of Technology, 2023-02)The challenge of turbulent heat flux has plagued the CFD modeling community for decades. A systemic dearth of adequate data has forced modelers to heavily rely on intuition and ad hoc reasoning to justify modeling choices. ... -
A Hybrid Discrete and Continuum Framework for Multiscale Modeling
(Massachusetts Institute of Technology, 2023-06)From the agricultural and industrial products that use granular ingredients, to the geological systems below our feet, granular systems surround us. Developing a computational framework to simulate granular materials is ... -
A Language and Logic for Programming and Reasoning with Partial Observability
(Massachusetts Institute of Technology, 2024-02)Computer systems are increasingly deployed in partially-observable environments, in which the system cannot directly determine the environment’s state but receives partial information from observations. When such a computer ... -
A Manufacturing Methodology for Carbon Nanotube-based Digital Systems: from Devices, to Doping, to System Demonstrations
(Massachusetts Institute of Technology, 2022-02)Electronics is approaching a major paradigm shift because silicon transistor scaling no longer yields historical energy-efficiency benefits, spurring research towards beyond-silicon nanotechnologies. In particular, carbon ...