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Proton-coupled electron transfer : from basic principles to small molecule activation
(Massachusetts Institute of Technology, 2007)
Proton-coupled electron transfer (PCET) is the basic mechanism for bioenergetic conversion. Hallmark examples of such reactivities include water oxidation which is coupled to photosynthesis and oxygen reduction which is ...
Influence of DNA sequence context on O⁶-methylguanine mutagenicity in Escherichia coli
(Massachusetts Institute of Technology, 1999)
Non-traditional platinum compounds for improved cellular accumulation and tumor targeting
(Massachusetts Institute of Technology, 2009)
Chapter 1. Introduction to Non-Traditional Platinum Compounds for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration ...
Niobium-mediated synthesis of phosphorus-rich molecules
(Massachusetts Institute of Technology, 2010)
The use of a sterically demanding enolate ligand -OC[2Ad]Mes supported by niobium has allowed for the synthesis of (Mes[2Ad]CO) 3Nb=PP7Nb(OC [2Ad]Mes)3 through P4 coupling by a low-valent niobium intermediate. This asymmetric ...
Photoinduced phase transitions studied by femtosecond single-shot spectroscopy
(Massachusetts Institute of Technology, 2010)
Single-shot femtosecond spectroscopy has been developed and employed for the study of phase transitions of solid-state materials. Using two crossed echelons, a two dimensional spatial delay gradient was generated across a ...
Nickel-catalyzed preparation of acrylamides from alpha olefins and isocyanates ; Synthetic studies toward ripostatin A
(Massachusetts Institute of Technology, 2010)
Chapter I. In the presence of the N-heterocyclic carbene ligand IPr, the nickel(0)-catalyzed coupling reaction of a-olefins and branched aliphatic isocyanates provides c,-unsaturated amides arising from preferential C-C ...
Polaritonics : an intermediate regime between electronics and photonics
(Massachusetts Institute of Technology, 2005)
This thesis contains the foundational work behind the field of polaritonics. Corresponding to a frequency range from roughly 100 gigahertz up to 10 terahertz, polaritonics bridges the gap between electronics and photonics. ...
Synthesis and characterization of conducting polymers with new architectural motifs
(Massachusetts Institute of Technology, 2006)
Chapter one has a brief discussion of polythiophene and the important factors to consider with polythiophene synthesis and characterization. In chapter two, a variety of polythiophene derivatives that incorporated 2,2'-biphenyl ...
Laboratory measurements and modeling of trace atmospheric species
(Massachusetts Institute of Technology, 2005)
Trace species play a major role in many physical and chemical processes in the atmosphere. Improving our understanding of the impact of each species requires a combination of laboratory exper- imentation, field measurements, ...
Poly(phenylene ethynylene)s in biosensor applications
(Massachusetts Institute of Technology, 2005)
Conjugated polymers have shown remarkable sensitivity for the detection of a variety of analytes, ranging from explosives to biological molecules such as DNA. This thesis presents three new applications of poly(phenylene ...