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Structural specificity in coiled coils : a and d position polar residues
(Massachusetts Institute of Technology, 2001)
Experimental studies were performed to determine the effects of single polar residues at the a and the d positions of a reference coiled coil, GCN4-pVL. The reference coiled coil is very stable in solution and exists as a ...
Hormonal regulation of long chain fatty uptake by adipocytes and studies of FATP gene family
(Massachusetts Institute of Technology, 2001)
Long chain fatty acids (LCFA) are an important source of energy for most organisms. Serum fatty acid (FA) levels are dynamically regulated by hormones. We show that insulin directly stimulates adipocyte fatty acid influx ...
Serotonin-dependent modulation of Caenorthabditis elegans behaviors
(Massachusetts Institute of Technology, 2001)
Mouse modifiers of intestinal tumorigenesis
(Massachusetts Institute of Technology, 2001)
Colorectal cancer involves a series of molecular alterations as a normal cell progresses to malignancy. A large body of evidence points to the mutation of the APC gene as the pivotal event initiating intestinal tumorigenesis. ...
Genetic and biochemical analyses of succinoglycan, EPS II, and K antigen, polysaccharides important in the Sinorhizobium meliloti-alfalfa symbiosis
(Massachusetts Institute of Technology, 2001)
Characterization of three Drosophila melanogaster regulators of programmed cell death that lead to caspase activation
(Massachusetts Institute of Technology, 2001)
Programmed cell death plays an important part in metazoan development as well as in disease. The morphology of cells undergoing programmed cell death has been carefully defined and found to be conserved between a variety ...
Characterization of split ends, a new component of the Drosophila epidermal growth factor receptor signaling pathway
(Massachusetts Institute of Technology, 2001)
Split ends (spen) was isolated as a strong enhancer of the rough eye phenotype associated with constitutive activation of Yan, implicating spen as a positive regulator of the receptor tyrosine kinase (RTK) signaling pathway. ...
Lipopolysaccharide, K antigen, and other components of the bacterial cell surface important for S. meliloti-alfalfa symbiosis
(Massachusetts Institute of Technology, 2001)
Sinorhizobium meliloti can form a symbiotic relationship with alfalfa plants in which the bacteria fix atmospheric nitrogen into ammonia for the plant in exchange for nutrients. During this symbiosis, the bacteria live in ...
Regulation of tubulin functions in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2001)
A variety of cellular factors regulate the formation of complex microtubule structures in the cell. Most of these factors modulate microtubule structures by affecting the polymerization of [alpha]/[beta]-tubulin heterodimer ...
Structure determination of bacteriophage [phi]21 N-peptide and boxB RNA complex by NMR spectrocsopy
(Massachusetts Institute of Technology, 2001)
The antitermination protein N from [delta] and related E. coli bacteriophage interacts with the nut RNA site and host factors to transform RNA polymerase (RNAP) into a termination resistant transcription complex. The ...