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The identification of the mTOR-regulated phosphoproteome and a mediator of feedback inhibition to P13K-Akt
(Massachusetts Institute of Technology, 2011)
The mTOR protein kinase nucleates two complexes, mTORC1 and mTORC2. Collectively, the two complexes regulate processes important for cell growth and proliferation, including protein synthesis, autophagy, metabolism, and ...
Regulation of survival and synaptic connectivity in the adult brain by cell-intrinsic excitability
(Massachusetts Institute of Technology, 2011)
Although the lifelong addition of new neurons to the olfactory bulb and dentate gyms of mammalian brains is by now an accepted fact, the function of adult-generated neurons still largely remains a mystery. The ability of ...
Induced pluripotency and reprogramming by defined factors
(Massachusetts Institute of Technology, 2011)
The process by which the totipotent zygote undergoes development into an adult organism using a single genome is the foundation for epigenetics and cellular differentiation. Somatic cell nuclear transfer experiments (SCNT) ...
The C. elegans class A synthetic multivulva genes inhibit ectopic RAS-mediated vulval development by tightly restricting expression of lin-3 EGF
(Massachusetts Institute of Technology, 2011)
The class A and B synthetic multivulva (synMuv) genes of C. elegans redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. The class B synMuv genes encode many proteins known to remodel chromatin ...
A study of mammalian microRNA-mediated repression of gene expression by ribosome profiling
(Massachusetts Institute of Technology, 2011)
All cells in a multicellular organism carry the same genes, yet these same genes direct the differentiation of many different cell types. This is facilitated by differential gene expression, the control of which can be ...
The characterization of human [gamma]D-crystallin mutants and their differential interactions with the lens chaperone [alpha]B-crystallin
(Massachusetts Institute of Technology, 2011)
Cataract, the leading cause of blindness worldwide, is the opacification of the eye lens. In.age-related cataract, as well as roughly one half of congenital cataract cases, aggregation or precipitation of crystallin proteins ...
Identification of TICRR, a novel checkpoint and replication regulator
(Massachusetts Institute of Technology, 2011)
The eukaryotic cell cycle refers to a sequence of events by which a cell duplicates its genomic DNA and divides into two daughter cells. Deregulation of the cell cycle can cause aberrant cell proliferation, as well as ...
Site-specific protein labeling via sortase A and its applications/
(Massachusetts Institute of Technology, 2011)
Technological improvements in the assays and equipment used for biological, biochemical, biophysical and microscopy purposes have ensured that methods for labeling of proteins with reporter molecules remain in high demand. ...
The N-end rule degradation pathway : substrate recognition and staged delivery to the CIpAP protease by the CIpS adaptor protein
(Massachusetts Institute of Technology, 2011)
Regulated protein degradation is crucial in the regulation of many physiological processes as well as in protein quality control. In all organisms, ranging from bacteria to mammals, ATP-dependent proteases carry out regulated ...
Multiple roles of the replication initiation protein Cdtl during helicase loading in S. cerevisiae
(Massachusetts Institute of Technology, 2011)
The faithful transmission of genetic information is critical for the events of cell division and propagation. In eukaryotic cells, chromosomal replication is carefully coordinated with the cell cycle to ensure that the ...