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Investigations into therapeutic discovery and delivery of heparin-like glycosaminoglycans
(Massachusetts Institute of Technology, 2001)
Heparin-like glycosaminoglycans (HLGAGs) are complex polysaccharides found both in extracellular matrix (ECM) and at the cell surface where they, in a sequence-specific manner, bind to and regulate the biological activity ...
Analysis of community cancer mortality rates
(Massachusetts Institute of Technology, 2001)
Residents of small communities or neighborhoods often observe what appears to them to be an excessively high number of cancer cases. Some of these observations are brought to the attention of public health officials in the ...
Sequencing complex polysaccharides
(Massachusetts Institute of Technology, 2001)
Glycosaminoglycans are complex polysaccharides that exist at the cell/extracellular matrix interface. As such, these information-dense molecules are key regulators of extracellular signals. However, to date, there has been ...
Determination of the historical changes in primary and secondary risk factors for cancer using U.S. public health records
(Massachusetts Institute of Technology, 2001)
Overall cancer mortality rates have risen from about 4% of all deaths in the early 20th century to about 25% of all deaths by the end of the century in the United States. To assess any potential hypotheses for this increase ...
Nitric oxide : cellular effects in vitro and in vivo
(Massachusetts Institute of Technology, 2001)
The overall aim of this project was to investigate various cellular responses and toxic effects of nitric oxide, NO' and in vitro and in vivo. Nitric oxide gives rise to a complex spectrum of reactive species in oxygenated ...