Now showing items 1-4 of 4
A novel DNA damage quantification platform enables high throughput screening for genes that impact DNA double strand breaks
(Massachusetts Institute of Technology, 2018)
DNA is the blueprint of life, and the high fidelity transmission of genetic information from parent cells to progeny is essential for an organism's viability. However, our genomes are constantly being damaged by reactive ...
RNA sensing and programming platforms for mammalian synthetic Biology
(Massachusetts Institute of Technology, 2019)
The field of synthetic biology aims to control cellular behavior using programmable gene circuits. Generally these gene circuits sense molecular biomarkers, process these inputs and execute a desired calculated response. ...
Single-particle tracking and fluorescence correlation spectroscopy for systems-level analysis of molecular dynamics in diverse biological systems
(Massachusetts Institute of Technology, 2017)
Fluorescence microscopy has proven to be immensely powerful for the study of biological systems at both the cellular and systems biological levels. The ability to specifically label a single molecular species fluorescently ...
Biophysical responses of lymphocytes to environmental stress
(Massachusetts Institute of Technology, 2016)
Cellular biophysical properties both reflect and influence cell state. These parameters represent the consequences of the interactions of multiple molecular events, and thus may reveal information otherwise obscured when ...