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Hormonal regulation of long chain fatty uptake by adipocytes and studies of FATP gene family
(Massachusetts Institute of Technology, 2001)
Long chain fatty acids (LCFA) are an important source of energy for most organisms. Serum fatty acid (FA) levels are dynamically regulated by hormones. We show that insulin directly stimulates adipocyte fatty acid influx ...
Characterization of split ends, a new component of the Drosophila epidermal growth factor receptor signaling pathway
(Massachusetts Institute of Technology, 2001)
Split ends (spen) was isolated as a strong enhancer of the rough eye phenotype associated with constitutive activation of Yan, implicating spen as a positive regulator of the receptor tyrosine kinase (RTK) signaling pathway. ...
Characterization of three Drosophila melanogaster regulators of programmed cell death that lead to caspase activation
(Massachusetts Institute of Technology, 2001)
Programmed cell death plays an important part in metazoan development as well as in disease. The morphology of cells undergoing programmed cell death has been carefully defined and found to be conserved between a variety ...
Genetic and biochemical analyses of succinoglycan, EPS II, and K antigen, polysaccharides important in the Sinorhizobium meliloti-alfalfa symbiosis
(Massachusetts Institute of Technology, 2001)
Proteomic analysis of the function of DMPK, the myotonic dystrophy protein kinase
(Massachusetts Institute of Technology, 2001)
Myotonic Dystrophy type 1 (DM1), the most common form of adult-onset skeletal muscle dystrophy, is caused by expansion of a CTG repeat sequence embedded in the 3'UTR of a gene which encodes a serine threonine kinase, DMPK. ...
The roles of Cabin1 and Left1 in T cell development
(Massachusetts Institute of Technology, 2001)
Cabinl binds calcineurin and myocyte enhancer factor 2 (MEF2) through the C-terminal region. In cell lines, these interactions inhibit calcineurin activity following TCR signaling and transcriptional activation of Nur77 ...
The role of Xist RNA in the maintenance of X chromosome inactivation
(Massachusetts Institute of Technology, 2001)
The role of Xist RNA in silencing the inactive X of female somatic cells was investigated by generating a conditional allele of the Xist gene. A system was set up in which reactivation of two X-linked genes, the endogenous ...
Characterization of the histone deacetylation activity of the yeast silencing gene SIR2
(Massachusetts Institute of Technology, 2001)
A gene's location in the genome can have profound effects on its ekpression. In Saccharomyces cerevisiae, the gene SIR2 is crucial for silencing at the HM mating type loci, the telomeres, and the rDNA array. It is also ...
Genetic and biochemical analysis of the mammalian spindle assembly checkpoint
(Massachusetts Institute of Technology, 2001)
Mouse modifiers of intestinal tumorigenesis
(Massachusetts Institute of Technology, 2001)
Colorectal cancer involves a series of molecular alterations as a normal cell progresses to malignancy. A large body of evidence points to the mutation of the APC gene as the pivotal event initiating intestinal tumorigenesis. ...