Search
Now showing items 1-10 of 40
Functional connectivity of coral reef fishes in a tropical seascape assessed by compound-specific stable isotope analyses
(Massachusetts Institute of Technology, 2011)
The ecological integrity of tropical habitats, including mangroves, seagrass beds and coral reefs, is coming under increasing pressure from human activities. Many coral reef fish species are thought to use mangroves and ...
Protein quality control in the mammalian endoplasmic reticulum
(Massachusetts Institute of Technology, 2011)
Quality control is an important part of protein biogenesis. Aberrant proteins must be destroyed before they aggregate and cause deleterious effects. Failure to do so can result in cell death or malfunction and, ultimately, ...
pRb's role in cell fate, lineage commitment, and tumorigenesis
(Massachusetts Institute of Technology, 2011)
The product of the retinoblastoma gene, pRB, was the first known and cloned tumor suppressor gene and it is functionally inactivated in most human cancers. pRB is thought to suppresses tumorigenesis by restraining cellular ...
Life cycle studies of the red tide dinoflagellate species complex Alexandrium tamarense
(Massachusetts Institute of Technology, 2011)
Blooms of toxic species within the algal dinoflagellate species complex Alexandrium tamarense may cause Paralytic Shellfish Poisoning, a significant and growing environmental threat worldwide. However, blooms of closely ...
Transport activity dependent regulation of the yeast general amino acid permease
(Massachusetts Institute of Technology, 2011)
The general amino acid permease Gap1p of Saccharomyces cerevisiae scavenges amino acids from the extracellular medium for use as nitrogen sources in starvation conditions. Because unlimited uptake of both naturally occurring ...
Chromatin and transcriptional regulators act in a cascade to establish a bilateral asymmetry of the C. elegans nervous system
(Massachusetts Institute of Technology, 2011)
Neuroanatomical bilateral asymmetry is a widespread feature in both vertebrates and invertebrates. Although mostly bilaterally symmetric, the nervous system of Caenorhabditis elegans displays bilateral asymmetry. Bilateral ...
Modeling the processes affecting larval haddock (Melanogrammus aeglefinus) survival on Georges Bank
(Massachusetts Institute of Technology, 2011)
The ultimate goal of early life studies of fish over the past century has been to better understand recruitment variability. Recruitment is the single most important natural event controlling year-class strength and biomass ...
Investigating the initiation and progression of small cell lung cancer
(Massachusetts Institute of Technology, 2011)
Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...
Mechanisms of substrate recognition by the AAA+ protease HslUV
(Massachusetts Institute of Technology, 2011)
Protein degradation is a central component of all biological processes. The proteome must constantly change in response to environmental stimuli. As a result, protein synthesis and regulated proteolysis are vital to cell ...
Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model
(Massachusetts Institute of Technology, 2011)
Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...