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Promoter directionality is controlled by U1 snRNP and polyadenylation signals in mouse embryonic stem cells
(Massachusetts Institute of Technology, 2013)
RNA polymerase II (RNAPII) transcription is a tightly regulated process controlling cell type and state. Advancements in our understanding of how transcription is regulated will provide insight into the mechanisms controlling ...
Dual functions of the retinal determination gene network member EYES ABSENT as a transcription factor and protein phosphatase
(Massachusetts Institute of Technology, 2004)
Spatial and temporal coordination of genome segregation with activation of the Mitotic Exit Network
(Massachusetts Institute of Technology, 2012)
In budding yeast, an essential Hippo-like signal transduction cascade known as the Mitotic Exit Network (MEN) governs the final cell cycle transition, the mitosis to G1 transition. To ensure the accurate execution of ...
Gut-associated microbial symbionts of the marsh fiddler crab, Uca pugnax
(Massachusetts Institute of Technology, 2004)
(cont.) bacterial phylotypes. An exception was the U. pugnax hindgut phylotype most closely related to a phylotype identified from hindguts of the detritivorous shrimp Neotrypaea califomiensis. This finding suggests that ...
Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
(Massachusetts Institute of Technology, 2013)
The apicomplexan protozoan Toxoplasma gondii is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite ...
RNA polymerase II holoenzyme components and regulation
(Massachusetts Institute of Technology, 1999)
Patterns of linkage disequilibrium in the human genome
(Massachusetts Institute of Technology, 2002)
Although enormous progress has occurred in the field of human genetics, the cloning of complex trait mutations remains a challenging and unresolved process. This continuing difficulty is responsible for an ever-increasing ...
Identification and Characterization of Modulators of Chemotherapeutic Response in Mouse Models of Cancer
(Massachusetts Institute of Technology, 2010)
Chemotherapeutic drug resistance is a major cause of cancer treatment failure. While much attention has been focused on the genetics of tumor development, less is known about the genetic determinants of therapeutic outcome. ...
Molecular titration by MicroRNAs and target mimic inhibitors
(Massachusetts Institute of Technology, 2010)
MicroRNAs (miRNAs) are short, highly conserved non-coding RNA molecules that repress gene expression in a sequence-dependent manner. Each miRNA is predicted to target hundreds of genes, and a majority of protein-coding ...
The roles of Rb, p107, and E2f4 in bone formation and embryonic development
(Massachusetts Institute of Technology, 2007)
The pocket proteins, through their interaction with the E2F transcription factors, ensure the proper regulation of cell proliferation. By doing so, these protein complexes affect other fundamental processes such as ...