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Polyploidy in Saccharomyces cerevisiae leads to the loss of cell cycle control in stationary phase
(Massachusetts Institute of Technology, 2003)
Advances in genome sequencing and comparative genomics have uncovered ancient duplications in the genomes of many extant organisms. Evidence for large regional duplications is observed in eukaryotic organisms that include ...
Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
(Massachusetts Institute of Technology, 2003)
The E2F transcription factors are critical downstream targets of the retinoblastoma protein (pRB) pathway. A component of the pRB pathway is mutated in most human tumors resulting in deregulation of cell cycle control ...
Cloning, stem cells and epigenetic reprogramming after nuclear transfer
(Massachusetts Institute of Technology, 2003)
The process by which a single totipotent cell becomes a complex organism is a unidirectional program, with each mitotic division generating new cells that gradually differentiate towards more specified fates and specialized ...
The role of E2F·pocket protein repressive complexes in cell cycle control and differentiation
(Massachusetts Institute of Technology, 2003)
The pocket protein family is comprised of pRB (the protein product of the retinoblastoma susceptibility gene), p107, and p130. This family regulates the GI/S transition by interacting with their major downstream target, ...
Genetic and epigenetic regulation of the cell wall glycoproteins, Flo10p and Flo11p, generate phenotypic variation in S. cerevisiae
(Massachusetts Institute of Technology, 2003)
Many organisms, in response to selective pressures imposed by their environment, have evolved mechanisms that allow them to generate phenotypic variation. Such phenotypic variation can result from genetic regulation, in ...
Regulation of GAP1 permease sorting in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2003)
The intracellular sorting of the general amino acid permease (Gaplp) of Saccharomyces cerevisiae is regulated by the nitrogen source in the growth medium. During growth on a non-preferred nitrogen source or during nitrogen ...
Mechanism and consequences of Mu transpososome remodeling by the ClpX chaperone
(Massachusetts Institute of Technology, 2003)
E. coli ClpX is a member of the Clp/Hsp100 family of ATPases that remodel multi-component complexes and facilitate ATP-dependent protein degradation. Protein remodelers alter the biological activity of their substrates, ...
Old protein, new perspective : the role of Oct-1 during embryonic development and lymphopoiesis
(Massachusetts Institute of Technology, 2003)
B cell development consists of an ordered program of rearrangement and transcriptional events, leading ultimately to the expression of immunoglobulin (Ig) molecules. This process involves the interaction of cis acting ...
The degradation of membrane proteins from the mammalian endoplasmic reticulum
(Massachusetts Institute of Technology, 2003)
Membrane glycoproteins of the secretory pathway that cannot adopt their native conformation are targeted for dislocation from the endoplasmic reticulum (ER) membrane for subsequent degradation by the cytosolic proteasome. ...
Molecular analysis of kinetochore-microtubule attachment in budding yeast
(Massachusetts Institute of Technology, 2003)
Kinetochores bind to microtubules and are responsible for chromosome segregation and the accurate transmission of genetic information during cell division. Kinetochores are DNA-protein complexes that assemble on centromeric ...