Search
Now showing items 1-10 of 48
Mapping the core regulatory circuitry of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ...
Dissecting the transcriptional regulatory network of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
The process by which a single fertilized egg develops into a human being with over 200 cell types, each with a distinct gene expression pattern controlling its cellular state, is poorly understood. An understanding of the ...
Functional characterization and expression of molluscan detoxification enzymes and transporters involved in dietary allelochemical resistance
(Massachusetts Institute of Technology, 2008)
Understanding how organisms deal with potentially toxic or fitness-reducing allelochemicals is important for understanding patterns of predation and herbivory in the marine environment. The ability of marine consumers to ...
The rule of Myosin II and Rap2 in synaptic structure and function
(Massachusetts Institute of Technology, 2008)
Synapses, the connections between neurons, exhibit both structural and functional plasticity, and these changes could underlie learning and memory. Two synaptic phenomena that have been studied extensively are Hebbian ...
Tuning strength and specificity in the N-end rule
(Massachusetts Institute of Technology, 2008)
Protein degradation is a central mechanism in the regulation of gene expression and activity. Proteolysis regulates not only homeostatic activities, but also the cell's responses to stress. A recurring question underlying ...
Spatial and temporal population genetics at deep-sea hydrothermal vents along the East Pacific Rise and Galápagos Rift
(Massachusetts Institute of Technology, 2008)
Ecological processes at deep-sea hydrothermal vents on fast-spreading mid-ocean ridges are punctuated by frequent physical disturbance. Larval dispersal among disjunct vent sites facilitates the persistence of sessile ...
Echolocation-based foraging by harbor porpoises and sperm whales, including effects of noise and acoustic propagation
(Massachusetts Institute of Technology, 2008)
In this thesis, I provide quantitative descriptions of toothed whale echolocation and foraging behavior, including assessment of the effects of noise on foraging behavior and the potential influence of ocean acoustic ...
C. elegans integrates food, stress, and hunger signals to coordinate motor activity
(Massachusetts Institute of Technology, 2008)
In the presence of a bacterial food source, the small nematode C. elegans greatly reduces its rate of locomotion. While mechanical agitation greatly stimulates the locomotion of well-fed animals on bacteria, it does not ...
Orchestration : the movement and vocal behavior of free-ranging Norwegian killer whales (Orcinus orca)
(Massachusetts Institute of Technology, 2008)
Studying the social and cultural transmission of behavior among animals helps to identify patterns of interaction and information content flowing between individuals. Killer whales are likely to acquire traits culturally ...
A survey of fly and nematode small RNAs by deep sequencing
(Massachusetts Institute of Technology, 2008)
Small RNAs of -22 nt length play a variety of roles in the biology of animals by repressing the translation or stimulating the degradation of complementary messenger RNAs. Depending on the structure of their precursors, ...