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Identification of new genes and pathways that act to delay C. elegans aging
(Massachusetts Institute of Technology, 2008)
Aging of an organism is determined by both stochastic and genetic components. The importance of genes is illustrated by the discovery of single gene mutations that alter lifespans of species ranging from invertebrates C. ...
Computational approaches for the design and prediction of protein-protein interactions
(Massachusetts Institute of Technology, 2007)
There is a large class of applications in computational structural biology for which atomic-level representation is crucial for understanding the underlying biological phenomena, yet explicit atomic-level modeling is ...
Approaches for assessing the presence and impact of thyroid hormone disrupting chemicals in Delphinid cetaceans
(Massachusetts Institute of Technology, 2006)
Cetacean blubber is a primary site for lipid storage, which the animal utilizes during periods of energetic stress. It is important to understand how the blubber responds to factors such as ontogeny, water temperature, ...
Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations
(Massachusetts Institute of Technology, 2006)
Energy intake of individuals affects growth of organisms and, therefore, populations. Persistent lipophilic toxicants acquired with the energy can bioaccumulate and harm individuals. Marine mammals are particularly vulnerable ...
Biophysical coupling between turbulence, veliger behavior, and larval supply
(Massachusetts Institute of Technology, 2005)
The goals of this thesis were to quantify the behavior of gastropod larvae (mud snails Ilyanassa obsoleta) in turbulence, and to investigate how that behavior affects larval supply in a turbulent coastal inlet. Gastropod ...
Structural studies of the human polymeric immunoglobulin receptor
(Massachusetts Institute of Technology, 2005)
The human polymeric immunoglobulin receptor, pIgR, is a glycosylated type I transmembrane protein expressed on the basolateral surface of secretory epithelial cells. pIgR plays a key role in mucosal immunity and, together ...
Inhibition of IFN-[gamma] promoter function by site-specific methylation
(Massachusetts Institute of Technology, 2006)
When they become activated, naive helper T cells are able to polarize into either THI cells or TH2 cells. Development of naive CD4+ T cells into TH1 cells is characterized by the expression of IFN-y and the silencing of ...
Structural studies of rebeccamycin, staurosporine, and violacein biosynthetic enzymes
(Massachusetts Institute of Technology, 2008)
The biosynthesis of medically relevant bisindole natural products rebeccamycin, staurosporine, and violacein from the common starting material L-tryptophan involves shared enzymatic transformations. However, the pathways ...
MicroRNAs in early embryonic development : dissecting the role of miR-290 through miR-295 in the mouse
(Massachusetts Institute of Technology, 2008)
MicroRNAs mediate developmental regulation of gene expression via translational repression of target mRNAs. Targeted deletion of the miRNA biogenesis machinery in the mouse has demonstrated essential roles for miRNAs during ...
The genetics of the sexually dimorphic deaths of the C. elegans CEM neutrons
(Massachusetts Institute of Technology, 2009)
The cells of metazoan organisms possess the capability to commit a form of cellular suicide known as programmed cell death or apoptosis. The proper control of this endogenous death program is essential to animal development ...