Search
Now showing items 1-10 of 477
The role of ERO1 in oxidative protein folding in the endoplasmic reticulum
(Massachusetts Institute of Technology, 1999)
The formation of native disulfide bonds is critical for the folding and stability of many secreted proteins. We describe an essential S. cerevisiae gene, ER01, which encodes a conserved ER membrane protein required for ...
Sequence of the chicken sex chromosomes
(Massachusetts Institute of Technology, 2010)
In birds, as in mammals, the chromosome complement determines sex. Male birds are designated ZZ, female ZW. Mammals have the opposite system; males are XY and females XX. Both the avian ZW and mammalian XY pair are believed ...
Experience-dependent dendrite remodeling of GABAergic interneurons in the adult visual cortex
(Massachusetts Institute of Technology, 2010)
An ever increasing amount of evidence is demonstrating that structural plasticity is a diverse and ongoing feature that contributes to plasticity in the adult brain. It was previously shown that dendritic arbors of inhibitory ...
The role of the de novo DNA methyltransferase Dnmt3a in the nervous system
(Massachusetts Institute of Technology, 2007)
DNA methylation is an important mechanism of gene regulation. Evidence is mounting that epigenetic mechanisms including that of DNA methylation operate in the nervous system. Genetic disruption of the de novo DNA ...
Modeling hematologic malignancies and their treatment in humanized mice
(Massachusetts Institute of Technology, 2010)
Approximately 10% of all cancer deaths in the United States are due to neoplasms of the hematopoietic system, such as leukemias and lymphomas. Genetically engineered mouse models of these diseases have yielded invaluable ...
Translational regulation by short RNAs in mammalian cells
(Massachusetts Institute of Technology, 2006)
The large complexity of animals is thought to depend upon the regulation of gene expression and not the number of genes in a genome. Gene expression is a highly conserved process in which genes encoded by DNA are transcribed ...
Redesigning specificity in miniproteins
(Massachusetts Institute of Technology, 2006)
This work focuses on designing specific miniprotein interactions using computational models and then testing these designs with experiments. Miniproteins are small, autonomously-folding proteins that are excellent for ...
The germline- and tissue-specific effects of endogenous point-mutant p53
(Massachusetts Institute of Technology, 2005)
p53 is frequently altered in human tumors through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of- function properties to p53. To ascertain the ...
Regulation of horizontal gene transfer by intercellular peptide signaling in Bacillus subtilis
(Massachusetts Institute of Technology, 2006)
Horizontal gene transfer plays an important role in bacterial evolution. Although acquisition of foreign DNA can be beneficial to cells, it can also be detrimental. Therefore, cells that possess mechanisms to regulate ...
The role of mammalian target of rapamycin complex 1 in hepatic physiology and disease
(Massachusetts Institute of Technology, 2010)
The multi-component kinase mTOR complex 1 (mTORC 1) coordinates nutrient and growth factor inputs with numerous downstream processes including protein translation, autophagy, metabolism and cell growth. We have found that ...