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Now showing items 101-110 of 287
Migratory patterns of American shad (Alosa sapidissima) revealed by natural geochemical tags in otoliths
(Massachusetts Institute of Technology, 2007)
Geochemical signatures in the otoliths of diadromous fishes may allow for retrospective analyses of natal origins. In an assessment of river-specific signatures in American shad (Alosa sapidissima), an anadromous clupeid ...
Hormonal regulation of long chain fatty uptake by adipocytes and studies of FATP gene family
(Massachusetts Institute of Technology, 2001)
Long chain fatty acids (LCFA) are an important source of energy for most organisms. Serum fatty acid (FA) levels are dynamically regulated by hormones. We show that insulin directly stimulates adipocyte fatty acid influx ...
The role of buried stack residues in the folding of the beta-helix domain of P22 tailspike
(Massachusetts Institute of Technology, 2007)
In-register, parallel alignment of similar or identical side chains is a common structural phenomenon in amyloid fibers. In the crystal structure of an amyloid fiber, these residues not only align, but take identical side ...
Palindromes on the human X chromosome : testis-biased transcription, gene conversion and evolution
(Massachusetts Institute of Technology, 2005)
Recent genomic studies of the Y chromosome revealed massive, testis-specific palindromes that span 30% of the chromosome and are subject to gene conversion. We conducted studies to determine whether similar palindromes ...
Characterization of a Drosophila model of Huntington's disease
(Massachusetts Institute of Technology, 2006)
Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...
Genomic analysis of mouse tumorigenesis
(Massachusetts Institute of Technology, 2006)
The availability of the human and mouse genome sequences has spurred a growing interest in analyzing mouse models of human cancer using genomic techniques. Comparative genomic studies on mouse and human tumors can be ...
Regulation of Mu transposition via communication between the transposase and Mu-encoded accessory protein
(Massachusetts Institute of Technology, 2007)
Transposable elements comprise a significant portion of both prokaryotic and eukaryotic genomes. These mobile segments of DNA have helped to shape the course of evolution by generating genetic mutations and contributing ...
The role of ZW10 and its binding partners in chromosome segregation
(Massachusetts Institute of Technology, 2007)
Kinetochores are proteinacious structures that assemble on centromeric DNA and fulfill several important functions during chromosome segregation. They attach chromosomes to microtubules of the mitotic spindle in a bipolar ...
[RNA polymerase ribozymes]
(Massachusetts Institute of Technology, 2005)
The RNA World is a hypothetical ancient evolutionary era during which RNA was both genome and catalyst. During that time, RNA was the only kind of enzyme yet in existence, and one of its chief duties was the replication ...
Genes with internal repeats require the THO complex for transcription
(Massachusetts Institute of Technology, 2006)
A genome-wide screen for promoter-independent regulators of the Saccharomyces cerevisiae adhesin FLOII identified 37 novel regulators. Among the mutants with the strongest phenotype were the deletions of genes encoding ...