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Structure determination of bacteriophage [phi]21 N-peptide and boxB RNA complex by NMR spectrocsopy
(Massachusetts Institute of Technology, 2001)
The antitermination protein N from [delta] and related E. coli bacteriophage interacts with the nut RNA site and host factors to transform RNA polymerase (RNAP) into a termination resistant transcription complex. The ...
The reaction kinetics and three-dimensional architecture of a catalytic RNA
(Massachusetts Institute of Technology, 2001)
The Class I ligase ribozyme was isolated previously from random sequences based on its ability to promote a reaction similar to a single step in RNA polymerization: attack of a primer 3'-hydroxyl on a 5'-triphosphate, with ...
GP96 and the immune response
(Massachusetts Institute of Technology, 2001)
Protein degradation from the endoplasmic reticulum in yeast
(Massachusetts Institute of Technology, 2001)
The majority proteins that misfold in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for degradation by the proteasome. This process of dislocation and degradation occurs in several steps. First, unfolded ...
Studies of DNA repair and mutagenesis in Escherichia coli and Bacillus subtilis
(Massachusetts Institute of Technology, 2001)
All organisms face constant challenges to the integrity of their genomes, from environmental agents such as ultraviolet light (UV) to errors generated by their own DNA polymerases. To deal with these challenges, all organisms ...
Structural specificity in coiled coils : a and d position polar residues
(Massachusetts Institute of Technology, 2001)
Experimental studies were performed to determine the effects of single polar residues at the a and the d positions of a reference coiled coil, GCN4-pVL. The reference coiled coil is very stable in solution and exists as a ...
Serotonin-dependent modulation of Caenorthabditis elegans behaviors
(Massachusetts Institute of Technology, 2001)
Lipid-protein interactions of immunoreceptor signaling subunit cytoplasmic domains
(Massachusetts Institute of Technology, 2001)
Protein-lipid interactions are emerging as key components of cellular processes such as protein and membrane trafficking and cell-cell signaling. Many proteins bind lipid reversibly, including cytoplasmic proteins involved ...
Lipopolysaccharide, K antigen, and other components of the bacterial cell surface important for S. meliloti-alfalfa symbiosis
(Massachusetts Institute of Technology, 2001)
Sinorhizobium meliloti can form a symbiotic relationship with alfalfa plants in which the bacteria fix atmospheric nitrogen into ammonia for the plant in exchange for nutrients. During this symbiosis, the bacteria live in ...
Regulation of tubulin functions in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2001)
A variety of cellular factors regulate the formation of complex microtubule structures in the cell. Most of these factors modulate microtubule structures by affecting the polymerization of [alpha]/[beta]-tubulin heterodimer ...