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pRb's role in cell fate, lineage commitment, and tumorigenesis
(Massachusetts Institute of Technology, 2011)
The product of the retinoblastoma gene, pRB, was the first known and cloned tumor suppressor gene and it is functionally inactivated in most human cancers. pRB is thought to suppresses tumorigenesis by restraining cellular ...
Life cycle studies of the red tide dinoflagellate species complex Alexandrium tamarense
(Massachusetts Institute of Technology, 2011)
Blooms of toxic species within the algal dinoflagellate species complex Alexandrium tamarense may cause Paralytic Shellfish Poisoning, a significant and growing environmental threat worldwide. However, blooms of closely ...
Mechanisms of regulation of the spindle position checkpoint kinase, Kin4
(Massachusetts Institute of Technology, 2010)
Most cells are polarized in that they are aware of spatial cues and can respond to these cues accordingly. One major aspect of cell function that is often responsive to these polarization cues is cell division. Cell division, ...
Tissue-specific interactions between oncogenic K-ras and the p19A̳r̳f̳_p53 pathway determine susceptibility to transformation
(Massachusetts Institute of Technology, 2010)
Tumor development is a multi-step process driven by the collective action of gain-of-function mutations in oncogenes and loss-of-function alterations in tumor suppressor genes. The particular spectrum of mutations in a ...
The localization of mTORC1 signaling
(Massachusetts Institute of Technology, 2010)
Cells sense and respond to their environment by maintaining appropriate activity levels and localizations of key signaling proteins. In eukaryotic cells, cell size is increasingly appreciated as being coordinated by the ...
Contributions of aromatic pairs of human Gamma-D-Crystallin to its folding, stability, aggregation, and interaction with human Alpha B-Crystallin
(Massachusetts Institute of Technology, 2012)
Two distinct groups of proteins, a-crystallins and [Beta][gamma]-crystallins, constitute 90% of the vertebrate eye lens soluble proteins. Long-term solubility and stability against unfolding and aggregation are essential ...
Phosphorus physiology of the marine cyanobacterium Trichodesmium
(Massachusetts Institute of Technology, 2010)
Primary producers play a critical role in the oceanic food chain and the global cycling of carbon. The marine diazotroph Trichodesmium is a major contributor to both primary production and nitrogen fixation in the tropical ...
Structural elucidation of a common architecture of the nuclear pore complex and COPIl vesicle coats
(Massachusetts Institute of Technology, 2010)
Nuclear pore complexes (NPCs) are massive protein assemblies that perforate the nuclear envelope and form the exclusive passageway for nucleocytoplasmic transport. NPCs play critical roles in molecular transport and a ...
Roles for chromatin regulators during differentiation of embryonic stem cells
(Massachusetts Institute of Technology, 2012)
Mammalian development involves the process by which a single fertilized egg develops into an adult with over 200 specialized cell types, each with a distinct gene expression pattern controlling its cellular state. As cells ...
The role of Huntingtin in fast axonal transport
(Massachusetts Institute of Technology, 2012)
Huntington's Disease (HD) is an autosomal dominant, neurodegenerative disease that occurs when an expansion of the polyQ tract of the huntingtin gene expands to greater than ~35 residues. This mutation leads to aggregation ...