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Structural specificity in coiled coils : a and d position polar residues
(Massachusetts Institute of Technology, 2001)
Experimental studies were performed to determine the effects of single polar residues at the a and the d positions of a reference coiled coil, GCN4-pVL. The reference coiled coil is very stable in solution and exists as a ...
Retrograde regulation of activity-dependent synaptic growth by Synaptotagmin 4
(Massachusetts Institute of Technology, 2009)
Ca2+ influx into pre- and post-synaptic compartments during neuronal activity is a key mediator of neurotransmitter release and synaptic plasticity. Although the role of presynaptic Ca2+ in triggering vesicle fusion is ...
Regulation and functions of Cdc14 in mitotic exit in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2009)
In order to ensure the accurate formation of two daughter cells from one parental cell, the series of events that comprise the mitotic cell division cycle must be carefully regulated. Much of this regulation affects the ...
Mapping the core regulatory circuitry of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ...
Dissecting the transcriptional regulatory network of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
The process by which a single fertilized egg develops into a human being with over 200 cell types, each with a distinct gene expression pattern controlling its cellular state, is poorly understood. An understanding of the ...
The rule of Myosin II and Rap2 in synaptic structure and function
(Massachusetts Institute of Technology, 2008)
Synapses, the connections between neurons, exhibit both structural and functional plasticity, and these changes could underlie learning and memory. Two synaptic phenomena that have been studied extensively are Hebbian ...
Tuning strength and specificity in the N-end rule
(Massachusetts Institute of Technology, 2008)
Protein degradation is a central mechanism in the regulation of gene expression and activity. Proteolysis regulates not only homeostatic activities, but also the cell's responses to stress. A recurring question underlying ...
MicroRNAs in cellular transformation and tumorigenesis
(Massachusetts Institute of Technology, 2009)
MicroRNAs (miRNAs) are a novel class of small (approximately 23 nucleotides long), highly conserved, non-coding RNAs that function by broadly regulating gene expression. In animals, this regulation is achieved via interaction ...
Preventing aneuploidy and the consequences of failure
(Massachusetts Institute of Technology, 2009)
The maintenance and transmission of genetic material is critical for the survival of cells and organisms. Sexually reproducing diploid organisms undergo meiosis to produce haploid gametes, so that the resulting progeny are ...
DNA damage tolerance and mutagenesis : the regulation of S. cerevisiae Rev1
(Massachusetts Institute of Technology, 2009)
DNA damage constantly challenges the integrity of genetic material during the lifetime of every cell. Accurate duplication of DNA and its proper transmission to a new cell are critical to avoid mutations or loss of genetic ...