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The identification of the mTOR-regulated phosphoproteome and a mediator of feedback inhibition to P13K-Akt
(Massachusetts Institute of Technology, 2011)
The mTOR protein kinase nucleates two complexes, mTORC1 and mTORC2. Collectively, the two complexes regulate processes important for cell growth and proliferation, including protein synthesis, autophagy, metabolism, and ...
Regulation of survival and synaptic connectivity in the adult brain by cell-intrinsic excitability
(Massachusetts Institute of Technology, 2011)
Although the lifelong addition of new neurons to the olfactory bulb and dentate gyms of mammalian brains is by now an accepted fact, the function of adult-generated neurons still largely remains a mystery. The ability of ...
Induced pluripotency and reprogramming by defined factors
(Massachusetts Institute of Technology, 2011)
The process by which the totipotent zygote undergoes development into an adult organism using a single genome is the foundation for epigenetics and cellular differentiation. Somatic cell nuclear transfer experiments (SCNT) ...
Prion protein in health and disease
(Massachusetts Institute of Technology, 2008)
The prion protein (PrP) is a conserved glycoprotein tethered to cell membranes by a glycosylphosphatidylinositol anchor. In mammals, PrP is expressed in many tissues, most abundantly in brain, heart, and muscle. Importantly, ...
Heat shock proteins as immunological carriers
(Massachusetts Institute of Technology, 1998)
Amino acids regulate the transcription, internal sorting, and intrinsic activity of the general amino acid permease (GAP1) in S. cerevisiae
(Massachusetts Institute of Technology, 2007)
The high capacity general amino acid permease in Saccharomyces cerevisiae (GAP1) is regulated such that it actively imports amino acids into the cell from the extracellular medium only when internal amino acid levels are ...
Quantitative analysis of apoptotic decisions in single cells and cell populations
(Massachusetts Institute of Technology, 2007)
Apoptosis is a form of programmed cell death that is essential for the elimination of damaged or unneeded cells in multicellular organisms. Inactivation of apoptotic cell death is a necessary step in the development of ...
Novel regulatory mechanisms of mutagenic translesion DNA synthesis : characterization of REV1 in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2007)
Cells are constantly subjected to DNA damage from endogenous and exogenous sources. Spontaneous DNA damage alone accounts for -30,000 DNA lesions per day in a mammalian cell. Cells are also exposed to an enormous variety ...
Genetic analysis of the maintenance of neuronal morphology in Drosophila melanogaster
(Massachusetts Institute of Technology, 2006)
Precise control of cellular morphology is critical for both the development and maintenance of nervous systems. In the developing Drosophila eye, normal photoreceptor cells establish and maintain a highly polarized ...
The developmental role and regulation of the Anaphase-Promoting Complex/Cyclosome in Drosophila meiosis
(Massachusetts Institute of Technology, 2008)
Meiosis is a modified cell cycle in which two round of chromosome segregation occur without an intervening DNA synthesis phase. As in mitosis, these cell divisions are driven in part by proteolysis mediated by the ...