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Degradation of the E. coli small heat-shock proteins by the AAA+ protease lon : significance to protein quality-control
(Massachusetts Institute of Technology, 2010)
The refolding and elimination of damaged and aggregated proteins requires the concerted effort of several branches of the protein quality-control network. This network includes refolding chaperones, disaggregases, holdases ...
Effects of aneuploidy on growth and cell cycle progression
(Massachusetts Institute of Technology, 2010)
In budding yeast, aneuploidy has a detrimental effect in cell growth and proliferation. The work presented here shows that most aneuploid yeast strains delay cell cycle entry by increasing the critical size for budding and ...
Development and functions of signature whistles of free-ranging bottlenose dolphins, Tursiops truncatus
(Massachusetts Institute of Technology, 1992)
Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis
(Massachusetts Institute of Technology, 2009)
Nearly 90% of cancer mortality from solid tumors is due to metastasis of malignant cells to the distant vital organs. It is now well established that a plethora of stromal cells are present within the tumor, and contribute ...
Nutrient sensing by the mTORC1 pathway in physiology
(Massachusetts Institute of Technology, 2022-05)
Cellular growth and metabolism must be linked to the environmental status of the cell to maintain organismal function. This coordination is achieved by mTORC1, a master growth regulator that senses and integrates a diverse ...
Experimental design and analysis for high-parameter spatial omics
(Massachusetts Institute of Technology, 2022-05)
Recent decades have witnessed the dawn of an era of molecular biology as a data science. Technological advancements have enabled high-parameter molecular measurements (“omics”) to progress from bulk data, averaged across ...
An ORC Flip Enables Bidirectional Helicase Loading
(Massachusetts Institute of Technology, 2022-05)
Cells must duplicate their genetic material faithfully in every cell cycle to maintain cellular identity and ensure viability. The first step in DNA replication is the licensing of all potential origins by loading two ...
Analyzing the Role of Mucin O-Glycans in Regulating Microbial Virulence
(Massachusetts Institute of Technology, 2022-05)
Mucus is the principal ecological niche for the human microbiota, acting as an interface between the trillions of microorganisms residing in the mucosal surfaces of the body and the underlying epithelial cells. Here, mucus ...
Exploring the Activation Landscape of Pro-Apoptotic BAK Through the Discovery of Human BH3-Only and Non-Native Peptide Binders
(Massachusetts Institute of Technology, 2022-05)
BAK is one of the two pro-apoptotic members that form part of the BCL-2 protein family. Previous work has shown that binding of certain BH3-only proteins such as truncated BID (tBID), BIM, and PUMA to pro-apoptotic BAK ...
Interplay between an integrative and conjugative element and its bacterial host
(Massachusetts Institute of Technology, 2022-05)
Horizontal gene transfer is the mechanism by which bacteria acquire new genes. Mobile genetic elements (MGEs) are the primary drivers of horizontal gene transfer, introducing large fragments of DNA. Often, MGEs contain ...