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Characterization of anti-tumor T cell specificities to inform engineering of antigen-targeted immunotherapies
(Massachusetts Institute of Technology, 2021-09)
Over the past several decades, advances in immunotherapy have revolutionized cancer treatment. Immune checkpoint blockade has resulted in durable responses for some patients, but others have not seen the same benefits. T ...
RNA sensing and programming platforms for mammalian synthetic Biology
(Massachusetts Institute of Technology, 2019)
The field of synthetic biology aims to control cellular behavior using programmable gene circuits. Generally these gene circuits sense molecular biomarkers, process these inputs and execute a desired calculated response. ...
Single-particle tracking and fluorescence correlation spectroscopy for systems-level analysis of molecular dynamics in diverse biological systems
(Massachusetts Institute of Technology, 2017)
Fluorescence microscopy has proven to be immensely powerful for the study of biological systems at both the cellular and systems biological levels. The ability to specifically label a single molecular species fluorescently ...
Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy
(Massachusetts Institute of Technology, 2019)
Bone marrow stromal cells (BMSCs), a subset of which are considered mesenchymal stem cells (MSCs), have been used in over 600 clinical trials for indications ranging anywhere from autism to liver cirrhosis to diabetes. ...
The role of base excision repair proteins in the cellular responses to the anticancer drug cisplatin
(Massachusetts Institute of Technology, 2000)
Towards synthetic ecology : genetically programmable 4-module population control system in yeast
(Massachusetts Institute of Technology, 2014)
Communities of microorganisms are found nearly ubiquitously on earth. They survive and proliferate through interactions within and between microbial species, which are mediated by the exchange of small signaling modules. ...
Relating topology and dynamics in cell signaling networks
(Massachusetts Institute of Technology, 2009)
Cells are constantly bombarded with stimuli that they must sense, process, and interpret to make decisions. This capability is provided by interconnected signaling pathways. Many of the components and interactions within ...
Investigation of the mechanism of mutagenesis by the DNA adducts of the human bladder carcinogen, 4-aminobiphenyl
(Massachusetts Institute of Technology, 1992)
Engineering phosphorylation-dependent post-translational protein devices
(Massachusetts Institute of Technology, 2008)
One goal underlying synthetic biology is to develop standard biological parts that can be reliably assembled into devices encoding higher-order functions. Here, I developed a framework for engineering post-translational ...
Method for single-cell mass and electrophoretic mobility measurement
(Massachusetts Institute of Technology, 2010)
Analysis of single cells using flow cytometry techniques has created a wealth of knowledge about cellular phenomena that could not be obtained by population average measurements. As these techniques are integrated with ...