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Novel regulatory mechanisms of mutagenic translesion DNA synthesis : characterization of REV1 in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2007)
Cells are constantly subjected to DNA damage from endogenous and exogenous sources. Spontaneous DNA damage alone accounts for -30,000 DNA lesions per day in a mammalian cell. Cells are also exposed to an enormous variety ...
Genetic analysis of the maintenance of neuronal morphology in Drosophila melanogaster
(Massachusetts Institute of Technology, 2006)
Precise control of cellular morphology is critical for both the development and maintenance of nervous systems. In the developing Drosophila eye, normal photoreceptor cells establish and maintain a highly polarized ...
The developmental role and regulation of the Anaphase-Promoting Complex/Cyclosome in Drosophila meiosis
(Massachusetts Institute of Technology, 2008)
Meiosis is a modified cell cycle in which two round of chromosome segregation occur without an intervening DNA synthesis phase. As in mitosis, these cell divisions are driven in part by proteolysis mediated by the ...
Investigation of the role of chromosome missegregation in embryo development and in tumorigenesis
(Massachusetts Institute of Technology, 2002)
The separation and partitioning of sister chromatids prior to cytokinesis must be tightly regulated to insure that progeny cells receive the correct number of chromosomes. The spindle assembly checkpoint prevents chromosome ...
A two-color bacterial two-hybrid system for selecting sequence-specific DNA-binding proteins via fluorescence activated cell sorting
(Massachusetts Institute of Technology, 2002)
Proteins that recognize specific DNA sequences play a major role in many biological processes, and the ability to select or design novel DNA binding proteins could have a major impact on many areas of biotechnology and ...
A genetic and biochemical analysis of the bacteriophage [lambda] cro protein
(Massachusetts Institute of Technology, 1988)
Regulation of mammalian neuronal circuit development by CPG 15
(Massachusetts Institute of Technology, 2012)
The orderly assembly of neuronal circuits is specified by developmental programs of gene expression, however, the final stage in circuit development, maturation and refinement of specific synaptic connections, is strongly ...
Degradation of the E. coli small heat-shock proteins by the AAA+ protease lon : significance to protein quality-control
(Massachusetts Institute of Technology, 2010)
The refolding and elimination of damaged and aggregated proteins requires the concerted effort of several branches of the protein quality-control network. This network includes refolding chaperones, disaggregases, holdases ...
Regulation of the actin cytoskeleton in the neuronal growth cone
(Massachusetts Institute of Technology, 2005)
During the development of the nervous system, axons and dendrites are guided to their targets throughout the brain and body through the detection of diffusible and surface-bound guidance cues. The growth cone, a specialized ...
Integration of the phosphorylation-dependent signaling in the DNA damage response network : implications for cancer
(Massachusetts Institute of Technology, 2005)
The cellular response to DNA damage is an evolutionarily conserved process mediated by Ser/Thr kinases that results in the formation of multiple protein-protein complexes designed to control the cell cycle. The assembly ...