Search
Now showing items 31-40 of 48
Phosphorylation of the replicative helicase by the S-phase kinase, Dbf4-Cdc7, at origins of replication in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2008)
In eukaryotic cells, events such as DNA replication and mitosis must be carefully coordinated in the cell cycle to ensure that the entire genome is duplicated before cells undergo cell division. In particular, initiation ...
Sequence of the mouse Y chromosome
(Massachusetts Institute of Technology, 2008)
The mouse Y chromosome has been studied for over 50 years, from the early sex determination and immunological phenotypes attributed to it in the 1950s, to the several mouse Y permatogenic phenotypes and the sex ratio ...
Roles for motifs of cell cycle regulating kinases beyond substrate selection of individual kinases
(Massachusetts Institute of Technology, 2008)
Errors in the cell cycle, particularly during mitosis, have recently been implicated in tumorigenesis and cancer formation. Several protein kinases, including the major mitotic kinases Cdkl, Aurora A, Aurora B, Nek2, and ...
Control of HslUV protease function by nucleotide binding and hydrolysis
(Massachusetts Institute of Technology, 2008)
Many proteins act as molecular machines, using the power of nucleotide binding and hydrolysis to drive conformational changes in themselves and their target substrates. Like other AAA+ proteases, HslUV recognizes, unfolds, ...
C. elegans integrates food, stress, and hunger signals to coordinate motor activity
(Massachusetts Institute of Technology, 2008)
In the presence of a bacterial food source, the small nematode C. elegans greatly reduces its rate of locomotion. While mechanical agitation greatly stimulates the locomotion of well-fed animals on bacteria, it does not ...
Orchestration : the movement and vocal behavior of free-ranging Norwegian killer whales (Orcinus orca)
(Massachusetts Institute of Technology, 2008)
Studying the social and cultural transmission of behavior among animals helps to identify patterns of interaction and information content flowing between individuals. Killer whales are likely to acquire traits culturally ...
A survey of fly and nematode small RNAs by deep sequencing
(Massachusetts Institute of Technology, 2008)
Small RNAs of -22 nt length play a variety of roles in the biology of animals by repressing the translation or stimulating the degradation of complementary messenger RNAs. Depending on the structure of their precursors, ...
Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells
(Massachusetts Institute of Technology, 2008)
The epithelial cell adhesion molecule E-cadherin is often downregulated during carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin ...
The role of NK cells in selectin-dependent tumor suppression
(Massachusetts Institute of Technology, 2008)
Selectins are a small family of adhesion molecules that are critical for immune cell trafficking. In our laboratory, mice lacking all combinations of selectins have been generated. Previous work from our laboratory has ...
Mapping the core regulatory circuitry of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ...