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Mitotic regulators and their effects on Drosophila : chromosome structure during development
(Massachusetts Institute of Technology, 2005)
Variants of the canonical cell cycle are frequently used in nature to accomplish specific developmental goals. In one such variant, the endocycle, synthesis phase alternates with a gap phase without an intervening mitosis, ...
Genetic analysis of longevity in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2002)
Aging is a universal process that affects organisms from yeast to humans. Replicative life span in the budding yeast, Saccharomyces cerevisiae is defined as the number of daughter cells produced by a mother cell prior to ...
Structural specificity in coiled coils : a and d position polar residues
(Massachusetts Institute of Technology, 2001)
Experimental studies were performed to determine the effects of single polar residues at the a and the d positions of a reference coiled coil, GCN4-pVL. The reference coiled coil is very stable in solution and exists as a ...
Retrograde regulation of activity-dependent synaptic growth by Synaptotagmin 4
(Massachusetts Institute of Technology, 2009)
Ca2+ influx into pre- and post-synaptic compartments during neuronal activity is a key mediator of neurotransmitter release and synaptic plasticity. Although the role of presynaptic Ca2+ in triggering vesicle fusion is ...
Regulation and functions of Cdc14 in mitotic exit in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2009)
In order to ensure the accurate formation of two daughter cells from one parental cell, the series of events that comprise the mitotic cell division cycle must be carefully regulated. Much of this regulation affects the ...
Functional miRNA regulation of metastatic genes promotes tumor cell dissemination in non-small cell and small cell lung carcinomas
(Massachusetts Institute of Technology, 2013)
Tumor progression, from initiation to advanced metastatic disease, requires the orchestration of a diverse group of cell-intrinsic and extrinsic factors. This multifactorial disease is promoted by an accumulation of genetic ...
The role of the retinoblastoma protein in mitochondrial apoptosis
(Massachusetts Institute of Technology, 2013)
The retinoblastoma protein (pRB) tumor suppressor is deregulated in the vast majority of human tumors. pRB is a well-established transcriptional co-regulator that influences many fundamental cellular processes. It has been ...
Discovery and biochemical characterization of RNA interference in budding yeast
(Massachusetts Institute of Technology, 2013)
RNA interference (RNAi) is a eukaryotic pathway for the post-transcriptional regulation of gene expression. In the simplest form of RNAi, a double-stranded RNA (dsRNA) trigger is converted into small-RNA duplexes by the ...
Cell cycle regulation during gametogenesis in budding yeast
(Massachusetts Institute of Technology, 2013)
Sexual reproduction depends on meiosis, the specialized cell division that gives rise to gametes. During meiosis, two consecutive rounds of chromosome segregation follow one round of DNA replication to yield four haploid ...
Structure and function of the human Poly(ADP-ribose) polymerase enzyme family
(Massachusetts Institute of Technology, 2013)
The poly(ADP-ribose) polymerase (PARP) family of enzymes in humans is comprised of 17 proteins. PARP-1, the first member of the family, synthesizes a large, complex post-translational modification, poly(ADP-ribose). While ...