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Regulation of the Arf tumor suppressor by E2F transcription factors
(Massachusetts Institute of Technology, 2007)
Effective tumor suppression requires the appropriate function of two major signaling pathways, the pRB-E2F growth-control pathway and the p53 stress-response pathway. Members of the E2F family of transcription factors are ...
Autosomal random asynchronous replication is analogous to X-chromosome inactivation
(Massachusetts Institute of Technology, 2006)
A number of mammalian genes are expressed from only one of two alleles in either an imprinted or random manner. Those belonging to the random class include X-linked genes subject to X inactivation, as well as a number of ...
Folding, stability and aggregation of the long-lived eye lens protein human gamma D crystallin
(Massachusetts Institute of Technology, 2006)
Human [gamma]D crystallin (H[gamma]D-Crys) is a monomeric, two domain, primarily P-sheet protein found in high concentrations in the human eye lens. H[gamma]D-Crys and other crystallins are found in insoluble protein ...
Identification of new genes and pathways that act to delay C. elegans aging
(Massachusetts Institute of Technology, 2008)
Aging of an organism is determined by both stochastic and genetic components. The importance of genes is illustrated by the discovery of single gene mutations that alter lifespans of species ranging from invertebrates C. ...
Hormonal regulation of long chain fatty uptake by adipocytes and studies of FATP gene family
(Massachusetts Institute of Technology, 2001)
Long chain fatty acids (LCFA) are an important source of energy for most organisms. Serum fatty acid (FA) levels are dynamically regulated by hormones. We show that insulin directly stimulates adipocyte fatty acid influx ...
Computational approaches for the design and prediction of protein-protein interactions
(Massachusetts Institute of Technology, 2007)
There is a large class of applications in computational structural biology for which atomic-level representation is crucial for understanding the underlying biological phenomena, yet explicit atomic-level modeling is ...
Stability, unfolding, and aggregation of the gamma D and gamma S human eye lens crystallins
(Massachusetts Institute of Technology, 2007)
The transparency of the human eye lens depends on the properties of the a- crystallin and py-crystallin families of proteins, which accumulate to very high concentrations in mature lens fiber cells. The 0- and y-crystallins ...
Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts
(Massachusetts Institute of Technology, 2007)
Induction of angiogenesis is a critical and rate-limiting step in the progression of cancer. It is widely acknowledged that this induction requires the concomitant stimulation of pro-angiogenic and repression of anti-angiogenic ...
Regulation of E. coli SOS mutagenesis by dimeric intrinsically disordered umuD gene products
(Massachusetts Institute of Technology, 2007)
Products of the umuD gene in E. coli are involved in regulating the timing of error-free DNA repair processes and mutagenic translesion DNA synthesis (TLS) during the SOS response to DNA damage. Homodimeric UmuD2 is ...
Genetic approaches to studying coronary heart disease in SR-BI/apoE double knockout mice
(Massachusetts Institute of Technology, 2006)
Coronary heart disease (CHD) is a major healthcare concern in both developed and developing nations. The principal cause of CHD is atherosclerosis, the buildup of fatty deposits in vessel walls. SR-BI/apoE double knockout ...