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The spindle checkpoint : Bubs, Mads, and chromosome-microtubule attachment in budding yeast
(Massachusetts Institute of Technology, 2005)
(cont.) DNA damage response, we hypothesize that the perinuclear pool of Mad proteins may be required for spindle checkpoint-independent functions such as invoking metaphase arrest following DNA damage.
Investigation of the structure requirements for oligosaccharyl transferase function
(Massachusetts Institute of Technology, 2013)
N-linked glycosylation is a ubiquitous protein modification involved in a wide range of cellular functions and diseases (Varki, 1993). The oligosaccharyl transferase (OTase), the principle enzyme responsible for catalysis ...
Structural and biochemical analysis of the Y-shaped Nup84 subcomplex of the NPC
(Massachusetts Institute of Technology, 2012)
The eukaryotic cell is easily distinguishable from its prokaryotic counterpart through the presence of a complex endomembrane system. Most notable is the nucleus, which harbors and protects the genetic information of the ...
Investigating the role of the Caenorhabditis elegans unfolded protein response in immunity and development
(Massachusetts Institute of Technology, 2012)
Proteins destined for the secretory pathway are folded, posttranslationally modified, and assembled into complexes in the endoplasmic reticulum (ER). To maintain ER proteostasis, the rate of nascent peptide influx into the ...
The helical configuration of the polypeptide chains in collagen
(Massachusetts Institute of Technology, 1954)
Elucidating the functional states of tumor-resident dendritic cells that drive productive anti-tumor immunity
(Massachusetts Institute of Technology, 2022-02)
While checkpoint blockade immunotherapy (CBT) has demonstrated remarkable clinical efficacy, its success is tempered by an inability to induce responses in the majority of cancer patients. Efforts to understand mechanisms ...
The regulation of programmed and pathological cell death in C. elegans
(Massachusetts Institute of Technology, 2007)
Programmed cell death, or apoptosis, is important in the development and homeostasis of metazoans. In the nematode C. elegans, four genes, egl-1, ced-9, ced-4, and ced-3, constitute the core pathway acting in all somatic ...
Rescue of Fragile X Syndrome phenotypes in Fmr1 KO mice by the small molecule PAK inhibitor FRAX486
(Massachusetts Institute of Technology, 2012)
Autism is a diverse and complex family of disorders, and its prevalence is on the rise: 1 in 110 children have autism. There is no effective treatment for the symptoms which often include language and communication deficits, ...
Ena/VASP proteins regulate vertebrate nervous system development : a thesis presented
(Massachusetts Institute of Technology, 2004)
Nervous system development is a complex morphogenetic process. Cell migration, axon guidance and many other regulated cell shape changes build a functional nervous system. These processes depend upon regulation of the actin ...
Aromatic hydrocarbon metabolism by Rhodococcus sp. I24 : computational, biochemical and transcriptional analysis
(Massachusetts Institute of Technology, 2004)
Rhodococcus sp. 124 is a Gram-positive soil bacterium being developed for the manufacture of (-)cis-(1S,2R)-1-aminoindan-2-ol, a key precursor in the production of the HIV-1 protease inhibitor CrixivanTM, from the aromatic ...