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The role of the retinoblastoma protein in mitochondrial apoptosis
(Massachusetts Institute of Technology, 2013)
The retinoblastoma protein (pRB) tumor suppressor is deregulated in the vast majority of human tumors. pRB is a well-established transcriptional co-regulator that influences many fundamental cellular processes. It has been ...
Discovery and biochemical characterization of RNA interference in budding yeast
(Massachusetts Institute of Technology, 2013)
RNA interference (RNAi) is a eukaryotic pathway for the post-transcriptional regulation of gene expression. In the simplest form of RNAi, a double-stranded RNA (dsRNA) trigger is converted into small-RNA duplexes by the ...
Cell cycle regulation during gametogenesis in budding yeast
(Massachusetts Institute of Technology, 2013)
Sexual reproduction depends on meiosis, the specialized cell division that gives rise to gametes. During meiosis, two consecutive rounds of chromosome segregation follow one round of DNA replication to yield four haploid ...
Structure and function of the human Poly(ADP-ribose) polymerase enzyme family
(Massachusetts Institute of Technology, 2013)
The poly(ADP-ribose) polymerase (PARP) family of enzymes in humans is comprised of 17 proteins. PARP-1, the first member of the family, synthesizes a large, complex post-translational modification, poly(ADP-ribose). While ...
Molecular analysis of the Caenorhabditis elegans cell, lineage gene lin-11
(Massachusetts Institute of Technology, 1991)
The structural basis of RNA-catalyzed RNA polymerization
(Massachusetts Institute of Technology, 2010)
The Class I ligase is an artificial ribozyme that catalyzes a reaction chemically identical to a single turnover of RNA-dependent RNA polymerization. Such an activity would have been requisite for the emergence of a ...
Analysis of the role of the retinoblastoma susceptibility gene in murine development and tumorigenesis
(Massachusetts Institute of Technology, 1996)
Mapping the core regulatory circuitry of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ...
Dissecting the transcriptional regulatory network of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
The process by which a single fertilized egg develops into a human being with over 200 cell types, each with a distinct gene expression pattern controlling its cellular state, is poorly understood. An understanding of the ...
The rule of Myosin II and Rap2 in synaptic structure and function
(Massachusetts Institute of Technology, 2008)
Synapses, the connections between neurons, exhibit both structural and functional plasticity, and these changes could underlie learning and memory. Two synaptic phenomena that have been studied extensively are Hebbian ...