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Dual functions of the retinal determination gene network member EYES ABSENT as a transcription factor and protein phosphatase
(Massachusetts Institute of Technology, 2004)
Gut-associated microbial symbionts of the marsh fiddler crab, Uca pugnax
(Massachusetts Institute of Technology, 2004)
(cont.) bacterial phylotypes. An exception was the U. pugnax hindgut phylotype most closely related to a phylotype identified from hindguts of the detritivorous shrimp Neotrypaea califomiensis. This finding suggests that ...
Self-assembly of aurfactant-like amphiphilic peptides made of natural amino acids
(Massachusetts Institute of Technology, 2004)
Progress in biology has always been linked to the development of novel materials and techniques such as agar for bacterial culture, agarose for nucleic acid gel electrophoresis to new fluorescent molecules for microscopy. ...
Effects of the conserved proteins, Soj (ParA) and SpoOJ (ParB) on chromosome partitioning in Bacillus subtilis
(Massachusetts Institute of Technology, 2004)
The Par system contributes to stable inheritance of plasmids and chromosomes in diverse bacterial species. Faithful chromosome partitioning is important to dividing cells because anucleate, or chromosomeless, cells are not ...
Life cycle evolution and systematics of Campanulariid hydrozoans
(Massachusetts Institute of Technology, 2004)
The purpose of this thesis is to study campanulariid life cycle evolution and systematics. The Campanulariidae is a hydrozoan family with many life cycle variations, and provide an excellent model system to study life cycle ...
Catalysis of tubulin heterodimerization in vivo
(Massachusetts Institute of Technology, 2004)
The heterodimerization of α- and β-tubulin represents a critical early step in microtubule morphogenesis. In vitro studies have defined a pathway that mediates the incorporation of monomeric tubulin polypeptides into ...
Role of communication between subunits and enzymes in ClpXP-mediated substrate unfolding and degradation
(Massachusetts Institute of Technology, 2004)
Chaperones and proteases play important roles in quality control by helping proteins fold, by dismantling hyper-stable complexes, and by degrading unwanted proteins. The highly conserved AAA+ Clp/Hsp100 proteins are ATPases ...
Characterization of two Bacillus subtilis proteins required for the initiation, restart, and control of DNA replication
(Massachusetts Institute of Technology, 2004)
(cont.) This is consistent with an inability of dnaBS371P cells to adjust the frequency of initiation according to growth rate. I also found that cells over-producing DnaBS371P are filamentous, contain decreased DNA contents, ...
Investigation of the role of IQGAP1 in metastasis
(Massachusetts Institute of Technology, 2004)
Metastasis, or the spread of a primary tumor to distal sites in the body, is the major cause of human cancer-related morbidity and mortality. Metastasis requires a complex series of cellular events that remain poorly ...
p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts
(Massachusetts Institute of Technology, 2004)
The experiments presented in this thesis use mutation analysis, and study of the cells of mice with a deletion allele for the Trp53 gene, to explore both the regulation of p53, and its downstream functions mediated by ...