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The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development
(Massachusetts Institute of Technology, 2004)
Cell migration and axon guidance are highly similar processes important for the development of the nervous system. Both processes involve the transduction of signals across the membrane, resulting in changes in the ...
Studies on X chromosome inactivation and the X-linked disease Rett syndrome
(Massachusetts Institute of Technology, 2004)
(cont.) the RTT phenotype.
Molecular architecture of the Saccharomyces cerevisiae kinetochore
(Massachusetts Institute of Technology, 2004)
(cont.) checkpoint proteins Bub lp and Bub3p are recruited to the kinetochore as part of the normal cell cycle in budding yeast, whereas Madlp and Mad2p are recruited only in response to damage to the CEN-kinetochore-MT ...
Cell cycle regulation of complex formation at origins of DNA replications
(Massachusetts Institute of Technology, 2004)
This suggests that the S phase cyclin, which first activates DNA replication, then acts locally at the origin to prevent pre-RC formation.
Impaired and enhanced spatial representation of the PSD-95 knockout mouse
(Massachusetts Institute of Technology, 2004)
Postsynaptic density protein-95 (PSD-95) is the second most abundantly expressed synaptic protein in the postnatal forebrain. It is an integral part of the postsynaptic scaffolding complex and helps recruit receptors, ...
Characterization of a transcriptional response to population density in Bacillus subtilis
(Massachusetts Institute of Technology, 2004)
Bacteria keep track of their population density by using extracellular signaling molecules. In response to the accumulation of these signals, changes in gene expression coordinate the switch from unicellular activity to ...
Regulation of mitotic exit in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2004)
Successful cell division requires the coordination of several mitotic processes, such as chromosome segregation, spindle disassembly, and cytokinesis. Progression into mitosis is driven by mitotic cyclin dependent kinase ...
Dissecting the steps of substrate processing by the energy-dependent protease ClpXP
(Massachusetts Institute of Technology, 2004)
Intracellular proteolysis is carried out by self-compartmentalized, energy dependent proteases which contain a regulatory and a proteolytic component. The regulatory component, which contains ATPases, has crucial activities ...
Localization studies of sister-chromatid cohesion proteins MEI-S332 and RAD21 in Drosophila
(Massachusetts Institute of Technology, 2004)
In cell division, the proper segregation of chromosomes requires sister-chromatid cohesion. This physical attachment between sister chromatids is established during DNA replication, maintained throughout mitosis and released ...
Regulation of meiosis I chromosome segregation by Spol3 and Cdc5 in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2004)
Meiosis is a specialized cell cycle that generates gametes for the purpose of disseminating genetic material to the next generation. The reduction of chromosome number by half is brought about two chromosome segregation ...