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Investigating immune surveillance, tolerance, and therapy in cancer
(Massachusetts Institute of Technology, 2009)
Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems ...
Insights into the role and mechanism of the AAA+ adaptor Clps
(Massachusetts Institute of Technology, 2009)
Protein degradation is a vital process in cells for quality control and participation in regulatory pathways. Intracellular ATP-dependent proteases are responsible for regulated degradation and are highly controlled in ...
Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis
(Massachusetts Institute of Technology, 2009)
Nearly 90% of cancer mortality from solid tumors is due to metastasis of malignant cells to the distant vital organs. It is now well established that a plethora of stromal cells are present within the tumor, and contribute ...
A novel role for the transcriptional modulator NusA in DNA repair/damage tolerance pathways in Escherichia coli
(Massachusetts Institute of Technology, 2009)
All organisms must contend with the consequences of DNA damage, induced by a variety of both endogenous and exogenous sources. Mechanisms of DNA repair and DNA damage tolerance are crucial for cellular survival after DNA ...
The genetics of the sexually dimorphic deaths of the C. elegans CEM neutrons
(Massachusetts Institute of Technology, 2009)
The cells of metazoan organisms possess the capability to commit a form of cellular suicide known as programmed cell death or apoptosis. The proper control of this endogenous death program is essential to animal development ...
Flexibility and specificity of the interaction of MCL-1 with BIM BH3
(Massachusetts Institute of Technology, 2009)
Interactions among proteins of the BCL-2 family regulate apoptosis - the process of programmed cell death. This thesis focuses on interactions between anti-apoptotic BCL-2 proteins and BH3 peptides derived from pro-apoptotic ...
SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
(Massachusetts Institute of Technology, 2009)
As mammals age, osteoblast numbers decrease while osteoclast numbers increase, resulting in age-related or post-menopausal osteoporosis. SirT1, the mammalian orthologue of yeast Sir2, has been shown to be a negative regulator ...
A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line
(Massachusetts Institute of Technology, 2009)
IL-7R[alpha] is one component of the heterodimeric IL-7R[alpha] receptor, and signaling through this receptor is essential for murine T and B cell development as well as human T cell development. IL-7R[alpha] signaling is ...
Life in a drop of water
(Massachusetts Institute of Technology, 2009)
The last century of biology brought a revolution to our understanding of life at the molecular level; the last decade, a widening re-evaluation of the claim that understanding gained in vitro could reflect the true ...
Mechanisms for maintaining genomic integrity during chromosome segregation in budding yeast
(Massachusetts Institute of Technology, 2009)
Maintaining genomic integrity is crucial for an organism's fitness and survival. Regulation of chromosome segregation requires complex surveillance mechanisms that vary for different loci within the genome. This thesis ...