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Mechanisms and consequences of resistance to PRMT5 Inhibition
(Massachusetts Institute of Technology, 2021-06)
Drug resistance to cancer therapies poses a major clinical challenge and is a key obstacle to successful cancer treatment. Understanding how resistance develops and whether resistance brings new vulnerabilities, or collateral ...
Evolution of large palindromes on the primate X chromosome
(Massachusetts Institute of Technology, 2021-06)
Human sex chromosomes are enriched for complex genomic architecture, including massive palindromes with arms that can exceed 1 Mb in length and arm-to-arm sequence identity higher than 99%. Palindrome arms harbor protein-coding ...
A systematic approach for cataloging mTORC1 regulators
(Massachusetts Institute of Technology, 2021-06)
mTORC1 is a major regulator of eukaryotic cell growth. As a cellular decision-maker, mTORC1 surveils internal levels of basic biomolecules such as amino acids, ATP, cholesterol, and external levels of growth factors. Under ...
MFSD7C: A Solute Carrier Linking Heme and Calcium in Mitochondrial Energy Metabolism
(Massachusetts Institute of Technology, 2021-06)
Major Facilitator Superfamily Domain-Containing 7C (MFSD7C) is an orphan solute carrier. In humans, loss-of-function mutations in MFSD7C cause Fowler syndrome, an often prenatally lethal disorder that affects brain development ...
New tools for the discovery of pigment gene function
(Massachusetts Institute of Technology, 2021-06)
Dozens of genes contribute to the vast variation in human pigmentation. Many of these encode proteins that localize to the melanosome, the lysosome-related organelle that synthesizes pigment, but have unclear functions. ...
Redefining the Coordination of Gene Expression Machineries in Bacillus subtilis
(Massachusetts Institute of Technology, 2021-09)
Transcription-translation coupling has long been considered a defining feature of bacterial gene expression. As soon as the ribosome binding site emerges from the RNAP, the ribosome can initiate translation, and both ...
Environmental drivers of the abundance and distribution of forage fishes on the Northeast US shelf, with a particular emphasis on northern sand lance
(Massachusetts Institute of Technology, 2021-09)
Small pelagic fishes, also termed forage fishes, represent a critical link between secondary production and myriad top predators in marine ecosystems, including the Northeast US shelf. In this dissertation, I analyze the ...
Nucleoid condensation in Escherichia coli by the DNAbinding protein SymE
(Massachusetts Institute of Technology, 2021-09)
Bacteria are at the mercy of whatever environment surrounds them. As such, they have developed a number of clever methods to respond to the myriad of stressors that they face. Toxin-antitoxin (TA) systems are one of the ...
Investigating the role of a JNK-like MAP kinase signaling in regulating dauer developmental arrest in Caenorhabditis elegans
(Massachusetts Institute of Technology, 2021-09)
Many metazoans have the ability to respond to stressful growth environments by arresting in a diapause state. The young larvae of nematode Caenorhabditis elegans undergo drastic anatomic and metabolic remodeling to enter ...
Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
(Massachusetts Institute of Technology, 2021-09)
In genetically engineered mouse models of lung adenocarcinoma (LUAD), tumors become more heterogeneous and dysregulate cell identities as they progress and evolve. In this thesis, single-cell RNA-sequencing technology was ...