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GP96 and the immune response
(Massachusetts Institute of Technology, 2001)
Protein degradation from the endoplasmic reticulum in yeast
(Massachusetts Institute of Technology, 2001)
The majority proteins that misfold in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for degradation by the proteasome. This process of dislocation and degradation occurs in several steps. First, unfolded ...
The reaction kinetics and three-dimensional architecture of a catalytic RNA
(Massachusetts Institute of Technology, 2001)
The Class I ligase ribozyme was isolated previously from random sequences based on its ability to promote a reaction similar to a single step in RNA polymerization: attack of a primer 3'-hydroxyl on a 5'-triphosphate, with ...
Characterization of three Drosophila melanogaster regulators of programmed cell death that lead to caspase activation
(Massachusetts Institute of Technology, 2001)
Programmed cell death plays an important part in metazoan development as well as in disease. The morphology of cells undergoing programmed cell death has been carefully defined and found to be conserved between a variety ...
Genetic and biochemical analyses of succinoglycan, EPS II, and K antigen, polysaccharides important in the Sinorhizobium meliloti-alfalfa symbiosis
(Massachusetts Institute of Technology, 2001)
Characterization of split ends, a new component of the Drosophila epidermal growth factor receptor signaling pathway
(Massachusetts Institute of Technology, 2001)
Split ends (spen) was isolated as a strong enhancer of the rough eye phenotype associated with constitutive activation of Yan, implicating spen as a positive regulator of the receptor tyrosine kinase (RTK) signaling pathway. ...
Hormonal regulation of long chain fatty uptake by adipocytes and studies of FATP gene family
(Massachusetts Institute of Technology, 2001)
Long chain fatty acids (LCFA) are an important source of energy for most organisms. Serum fatty acid (FA) levels are dynamically regulated by hormones. We show that insulin directly stimulates adipocyte fatty acid influx ...
Mouse modifiers of intestinal tumorigenesis
(Massachusetts Institute of Technology, 2001)
Colorectal cancer involves a series of molecular alterations as a normal cell progresses to malignancy. A large body of evidence points to the mutation of the APC gene as the pivotal event initiating intestinal tumorigenesis. ...
Proteomic analysis of the function of DMPK, the myotonic dystrophy protein kinase
(Massachusetts Institute of Technology, 2001)
Myotonic Dystrophy type 1 (DM1), the most common form of adult-onset skeletal muscle dystrophy, is caused by expansion of a CTG repeat sequence embedded in the 3'UTR of a gene which encodes a serine threonine kinase, DMPK. ...
The roles of Cabin1 and Left1 in T cell development
(Massachusetts Institute of Technology, 2001)
Cabinl binds calcineurin and myocyte enhancer factor 2 (MEF2) through the C-terminal region. In cell lines, these interactions inhibit calcineurin activity following TCR signaling and transcriptional activation of Nur77 ...