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Drug resistance to cancer therapies poses a major clinical challenge and is a key obstacle to successful cancer treatment. Understanding how resistance develops and whether resistance brings new vulnerabilities, or collateral ...

Human sex chromosomes are enriched for complex genomic architecture, including massive palindromes with arms that can exceed 1 Mb in length and arm-to-arm sequence identity higher than 99%. Palindrome arms harbor protein-coding ...

mTORC1 is a major regulator of eukaryotic cell growth. As a cellular decision-maker, mTORC1 surveils internal levels of basic biomolecules such as amino acids, ATP, cholesterol, and external levels of growth factors. Under ...

Major Facilitator Superfamily Domain-Containing 7C (MFSD7C) is an orphan solute carrier. In humans, loss-of-function mutations in MFSD7C cause Fowler syndrome, an often prenatally lethal disorder that affects brain development ...

Dozens of genes contribute to the vast variation in human pigmentation. Many of these encode proteins that localize to the melanosome, the lysosome-related organelle that synthesizes pigment, but have unclear functions. ...