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High-throughput functionalization of the Toxoplasma kinome uncovers a novel regulator of invasion and egress
(Massachusetts Institute of Technology, 2022-05)
Protein kinases regulate fundamental aspects of eukaryotic cell biology, making them attractive chemotherapeutic targets in parasites like Plasmodium spp. and Toxoplasma gondii. To systematically examine the parasite kinome, ...
Regulation of Presynaptic Ca²⁺ Channel Abundance at Active Zones Through a Balance of Delivery and Turnover
(Massachusetts Institute of Technology, 2022-05)
Voltage-gated Ca²⁺ channels (VGCCs) mediate Ca²⁺ influx to trigger neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The abundance of VGCCs at AZs regulates neurotransmitter release ...
Noncanonical recognition and degradation of a stable soluble protein by AAA protease FtsH
(Massachusetts Institute of Technology, 2022-05)
AAA+ (ATPases associated with various cellular activities) proteolytic machines help maintain and adjust the cellular proteome in response to stress or changes in nutrients. AAA+ proteases bind degradation targets and ...
Establishment of MITF and TAZ as major determinants of uveal melanoma
(Massachusetts Institute of Technology, 2022-05)
Uveal melanoma (UM) is a cancer that arises from transformed melanocytes that exist in the uvea of the eye. Although UM is relatively rare, it is extremely deadly, due to the lack of treatment options for the metastatic ...
Repulsive axonal pathfinding requires the Ena/VASP family of actin regulatory proteins in vertebrates
(Massachusetts Institute of Technology, 2012)
Vertebrate nervous system development requires the careful interpretation of many attractive and repulsive guidance molecules. For the incredibly complicated wiring diagram comprising the vertebrate nervous system to ...
Mapping the core regulatory circuitry of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ...
Dissecting the transcriptional regulatory network of embryonic stem cells
(Massachusetts Institute of Technology, 2008)
The process by which a single fertilized egg develops into a human being with over 200 cell types, each with a distinct gene expression pattern controlling its cellular state, is poorly understood. An understanding of the ...
Pole cell determination and differentiation : a molecular screen for germ cell markers in Drosophila melanogaster
(Massachusetts Institute of Technology, 1995)
Creating a mouse model of neurofibromatosis type I : pathological and functional analysis of a tumor suppressor gene
(Massachusetts Institute of Technology, 1998)
Identification of novel genes regulated by innervation and characterization of subsynaptic proteins in skeletal muscle
(Massachusetts Institute of Technology, 1997)