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Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm
(Massachusetts Institute of Technology, 2002)
Specific interactions between heparan sulfate glycosaminoglycans (HSGAGs) and proteins are central to a wide range of biological processes such as anticoagulation, angiogenesis and growth factor activation. The specificity ...
Enzymatic and analytical tools for the characterization of chondroitin sulfate and dermatan sulfate glycosaminoglycans
(Massachusetts Institute of Technology, 2003)
Glycosaminoglycans (GAGs) are complex polysaccharides that reside in the extracellular matrix and on the surfaces of all cells. The same complexity that contributes to the diversity of GAG function has also hindered their ...
Glycomics : an emerging paradigm to protein-carbohydrate interactions
(Massachusetts Institute of Technology, 2003)
Glycosaminoglycans (GAGs) are a family of complex carbohydrates whose known biological roles have dramatically increased over the recent years. It is now becoming increasingly evident that sequence specific GAG-protein ...
Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice
(Massachusetts Institute of Technology, 2003)
Although homologous recombination provides an efficient means for repairing and tolerating DNA damage, mitotic recombination between misaligned sequences can lead to loss of genetic information (e.g. deletions, translocations ...
Engineering phosphorylation-dependent post-translational protein devices
(Massachusetts Institute of Technology, 2008)
One goal underlying synthetic biology is to develop standard biological parts that can be reliably assembled into devices encoding higher-order functions. Here, I developed a framework for engineering post-translational ...
Quantitative analysis of the receptor-induced apoptotic decision network
(Massachusetts Institute of Technology, 2008)
Cells use a complex web of protein signaling pathways to interpret extracellular cues and decide and execute cell fates such as survival, apoptosis, differentiation, and proliferation. Cell decisions can be triggered by ...
Noncovalent adsorption of nucleotides in gold nanoparticle DNA conjugates : bioavailability at the bio-nano interface
(Massachusetts Institute of Technology, 2008)
The practical viability of biomolecule-nanostructure hybrids depends critically on the functional and structural stability of biomolecules in application environments. Noncovalent interactions of biochemical functional ...
Tools and reference standards supporting the engineering and evolution of synthetic biological systems
(Massachusetts Institute of Technology, 2008)
Biological engineers have constructed a number of multi-part synthetic biological systems that conduct logical operations on input signals, produce oscillatory output signals, store memory, or produce desired products. ...
In vitro culture of a chondrocyte-seeded peptide hydrogel and the effects of dynamic compression
(Massachusetts Institute of Technology, 2003)
Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds ...
Nanoscale and microscale approaches for engineering the in vitro cellular microenvironment
(Massachusetts Institute of Technology, 2005)
Micro- and nanofabrication approaches have dramatically changed our society through their use in microelectronics and telecommunication industries. These engineering tools are also useful for many biological applications ...