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Old protein, new perspective : the role of Oct-1 during embryonic development and lymphopoiesis
(Massachusetts Institute of Technology, 2003)
B cell development consists of an ordered program of rearrangement and transcriptional events, leading ultimately to the expression of immunoglobulin (Ig) molecules. This process involves the interaction of cis acting ...
Genetic and epigenetic regulation of the cell wall glycoproteins, Flo10p and Flo11p, generate phenotypic variation in S. cerevisiae
(Massachusetts Institute of Technology, 2003)
Many organisms, in response to selective pressures imposed by their environment, have evolved mechanisms that allow them to generate phenotypic variation. Such phenotypic variation can result from genetic regulation, in ...
The degradation of membrane proteins from the mammalian endoplasmic reticulum
(Massachusetts Institute of Technology, 2003)
Membrane glycoproteins of the secretory pathway that cannot adopt their native conformation are targeted for dislocation from the endoplasmic reticulum (ER) membrane for subsequent degradation by the cytosolic proteasome. ...
The role of E2F·pocket protein repressive complexes in cell cycle control and differentiation
(Massachusetts Institute of Technology, 2003)
The pocket protein family is comprised of pRB (the protein product of the retinoblastoma susceptibility gene), p107, and p130. This family regulates the GI/S transition by interacting with their major downstream target, ...
Molecular analysis of kinetochore-microtubule attachment in budding yeast
(Massachusetts Institute of Technology, 2003)
Kinetochores bind to microtubules and are responsible for chromosome segregation and the accurate transmission of genetic information during cell division. Kinetochores are DNA-protein complexes that assemble on centromeric ...
Regulation of GAP1 permease sorting in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2003)
The intracellular sorting of the general amino acid permease (Gaplp) of Saccharomyces cerevisiae is regulated by the nitrogen source in the growth medium. During growth on a non-preferred nitrogen source or during nitrogen ...
Mechanism and consequences of Mu transpososome remodeling by the ClpX chaperone
(Massachusetts Institute of Technology, 2003)
E. coli ClpX is a member of the Clp/Hsp100 family of ATPases that remodel multi-component complexes and facilitate ATP-dependent protein degradation. Protein remodelers alter the biological activity of their substrates, ...
Analysis of the function of the Nf2 tumor suppressor protein, Merlin
(Massachusetts Institute of Technology, 2003)
The Neurofibromatosis type 2 tumor suppressor gene (NF2) is mutated in inherited and sporadically occurring central nervous system tumors. The NF2 encoded protein, merlin, shares close sequence similarity in its amino-terminal ...
Nucleotide recognition and metal ion requirements of an RNA ligase ribozyme
(Massachusetts Institute of Technology, 2003)
The class I ligase, a ribozyme previously isolated from random sequence, catalyzes a reaction similar to RNA polymerization, positioning its 5'-nucleotide via a Watson-Crick base pair, forming a 3',5'-phosphodiester bond ...
Regulation of the mitotic exit network components Tem1 and Cde 15 in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2003)
The division of a single eukaryotic cell resulting in two daughter progeny is controlled by cyclin dependent kinase activity (CDK). Mitotic cyclins associated with CDK promote the segregation of genetic material ensuring ...