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Approaches for assessing the presence and impact of thyroid hormone disrupting chemicals in Delphinid cetaceans
(Massachusetts Institute of Technology, 2006)
Cetacean blubber is a primary site for lipid storage, which the animal utilizes during periods of energetic stress. It is important to understand how the blubber responds to factors such as ontogeny, water temperature, ...
Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations
(Massachusetts Institute of Technology, 2006)
Energy intake of individuals affects growth of organisms and, therefore, populations. Persistent lipophilic toxicants acquired with the energy can bioaccumulate and harm individuals. Marine mammals are particularly vulnerable ...
Inhibition of IFN-[gamma] promoter function by site-specific methylation
(Massachusetts Institute of Technology, 2006)
When they become activated, naive helper T cells are able to polarize into either THI cells or TH2 cells. Development of naive CD4+ T cells into TH1 cells is characterized by the expression of IFN-y and the silencing of ...
Regulation of chromosome attachment and dynamics by Saccharomyces cerevisiae kinetochores
(Massachusetts Institute of Technology, 2006)
Kinetochores are large, multi-protein complexes that bind centromeric DNA to the microtubules of the mitotic spindle and mediate chromosome movement throughout the cell cycle. The proteins that regulate both force generation ...
Autosomal random asynchronous replication is analogous to X-chromosome inactivation
(Massachusetts Institute of Technology, 2006)
A number of mammalian genes are expressed from only one of two alleles in either an imprinted or random manner. Those belonging to the random class include X-linked genes subject to X inactivation, as well as a number of ...
Folding, stability and aggregation of the long-lived eye lens protein human gamma D crystallin
(Massachusetts Institute of Technology, 2006)
Human [gamma]D crystallin (H[gamma]D-Crys) is a monomeric, two domain, primarily P-sheet protein found in high concentrations in the human eye lens. H[gamma]D-Crys and other crystallins are found in insoluble protein ...
Genes with internal repeats require the THO complex for transcription
(Massachusetts Institute of Technology, 2006)
A genome-wide screen for promoter-independent regulators of the Saccharomyces cerevisiae adhesin FLOII identified 37 novel regulators. Among the mutants with the strongest phenotype were the deletions of genes encoding ...
Characterization of a Drosophila model of Huntington's disease
(Massachusetts Institute of Technology, 2006)
Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...
Genomic analysis of mouse tumorigenesis
(Massachusetts Institute of Technology, 2006)
The availability of the human and mouse genome sequences has spurred a growing interest in analyzing mouse models of human cancer using genomic techniques. Comparative genomic studies on mouse and human tumors can be ...
Analysis of cell cycle surveillance mechanisms in meiosis
(Massachusetts Institute of Technology, 2006)
Numerous DNA double-strand breaks (DSBs) are introduced into the genome in the course of meiotic recombination. This poses a significant hazard to the genomic integrity of the cell. Studies in a number of organisms have ...