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Integration of amino acid signals by the mTORC1 pathway
(Massachusetts Institute of Technology, 2022-09)
To regulate growth, cells must integrate a broad array of environmental cues to coordinate anabolic and catabolic processes. The mechanistic target of rapamycin complex 1 (mTORC1) kinase pathway is the primary eukaryotic ...
A small molecule-guided structure-function exploration of mitochondrial aldehyde dehydrogenase
(Massachusetts Institute of Technology, 2023-02)
Plants have been used as medicines in cultures across the globe for millennia. The pharmacological activity of plants is often derived from specialized metabolites, also called natural products. Despite this wealth of ...
A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
(Massachusetts Institute of Technology, 2022-02)
Accurate chromosome segregation during cell division is critical to cellular fitness and survival. Errors during the segregation process often lead to aneuploidy, a state where cells harbor whole chromosome gains or losses. ...
Trojan Horses in the Marine Realm: Characterizing Protistan Parasite Ecology in Coastal Waters
(Massachusetts Institute of Technology, 2022-02)
Protists are taxonomically and metabolically diverse drivers of energy and nutrient flow in the marine environment, with recent research suggesting significant roles in global carbon cycling throughout the water column. ...
Concentration-dependent Splicing through Suboptimal Motifs Enables Waves of Gene Regulation in Neuronal Development
(Massachusetts Institute of Technology, 2022-02)
Alternative splicing, which occurs in over 95% of human genes, is the process by which exons are differentially included in transcripts produced from the same gene to produce a variety of transcript isoforms. This mode of ...
How short, degenerate motifs across the human proteome recognize the actin remodeling factor ENAH
(Massachusetts Institute of Technology, 2022-02)
Protein-protein interactions form the backbone of the myriad signaling pathways that cells use to respond to their environments. A central class of protein-protein interactions in eukaryotic interactomes are those that ...
Assessing anthropogenic noise impacts and relevant soundscape cues for marine invertebrates: leveraging squid and coral reefs as model systems
(Massachusetts Institute of Technology, 2021-09)
Sound is utilized by marine animal taxa for many ecologically important functions, and these taxa are vulnerable to adverse effects of anthropogenic noise on hearing and behavior. However, little is known about marine ...
The Benefits and Detriments of Aneuploidy in Cancer
(Massachusetts Institute of Technology, 2022-02)
Aneuploidy, defined as having a chromosome number that is not a multiple of the organism’s haploid number, is a hallmark of cancer. This creates an imbalanced karyotype, where the copy number of hundreds or thousands of ...
New tools for the discovery of pigment gene function
(Massachusetts Institute of Technology, 2021-06)
Dozens of genes contribute to the vast variation in human pigmentation. Many of these encode proteins that localize to the melanosome, the lysosome-related organelle that synthesizes pigment, but have unclear functions. ...
Dynamic properties of the constitutive centromere associated network of proteins
(Massachusetts Institute of Technology, 2022-02)
Ensuring the proper transmission of genetic material across generations is fundamental to the propagation of cellular life. In each mitotic cell division, a series of highly regulated processes ensure that the genetic ...