Search
Now showing items 21-30 of 37
A new mouse model to probe the role of aflatoxin B₁ in liver carcinogenesis
(Massachusetts Institute of Technology, 2010)
One and a half million new cancer cases are reported each year in the United States. Despite this overwhelming burden of disease, current preventative treatments and early detection techniques are inadequate. With cancers, ...
Electro-chemical stimulation of neuromuscular systems using ion-selective membranes : flexible device fabrication and motor unit recruitment order
(Massachusetts Institute of Technology, 2013)
Spinal Cord injury (SCI) leads to paralysis, decrease in quality of life and high lifetime medical costs. Direct nerve Functional Electrical Stimulation (FES) induces muscles to contract by electrically stimulating nerves, ...
The growth and stress response characterization of Synechococcus WH8109 cyanobacteria
(Massachusetts Institute of Technology, 2009)
Oceanic cyanobacteria are amongst the most populous species on the planet and have been found in every ocean around the world. These photosynthetic organisms play a major role in the global carbon cycle. They have adapted ...
Modulation of the response to cisplatin by nitric oxide and reactive oxygen species in melanoma cells
(Massachusetts Institute of Technology, 2013)
Malignant melanoma causes the highest mortality rate in skin cancers. Although cisplatin has proved efficacious in the treatment of various solid tumors, melanoma seems particularly resistant to this chemotherapeutic drug. ...
Towards a carbon nanotube antibody sensor
(Massachusetts Institute of Technology, 2012)
This work investigated single-walled carbon nanotube (SWNT)/polymer-protein A complexes for optically reporting antibody concentration via a change in near infrared fluorescent emission after antibody binding. SWNT have ...
Transcriptional profiling of rat primary hepatocytes cultured in a 3D microfabricated liver reactor
(Massachusetts Institute of Technology, 2003)
Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro
(Massachusetts Institute of Technology, 2020)
Tau neurofibrillary tangles or aggregates are a common neuropathological feature found in a number of neurodegenerative conditions, including Alzheimer's disease. Understanding the kinetics of this aggregate build up, how ...
A rapid, flexible and scalable DNA assembly platform for genome engineering and regulated gene expression applications in Plasmodium falciparum
(Massachusetts Institute of Technology, 2015)
Plasmodium falciparum is the deadliest malaria parasite. There is no approved vaccine to prevent this disease, and resistance to available antimalarial drugs is becoming widespread. Identification of parasite genes essential ...
Integration of metabolic modelling with machine learning to identify mechanisms underlying antibiotic killing
(Massachusetts Institute of Technology, 2017)
Microbial pathogens are becoming a pressing global health issue due to the rapid appearance of resistant strains, accompanied by slow development of new antibiotics. In order to improve these treatments and engineer novel ...
Computational modeling and simulation for projectile impact and indentation of biological tissues and polymers
(Massachusetts Institute of Technology, 2017)
Understanding the elastic and viscoelastic responses of biological soft tissues and engineered polymer simulants is of great interest to predicting and preventing penetrative injuries. Detailed understanding of the mechanical ...