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Now showing items 11-20 of 328
Development of a risk management system for consumables used in biopharmaceutical manufacturing
(Massachusetts Institute of Technology, 2013)
Injectable drugs, like those manufactured by the BioPharmOps group of Novartis Pharmaceuticals AG, must conform to strict guidelines for purity and potency. Recent non-conformances of critical supplied consumables have ...
Managing expectations during acquisition of bespoke automation systems
(Massachusetts Institute of Technology, 2016)
A new facility seeks to manufacture inlets for the turbine of the new NDA aircraft. The inlet is a new design and has never been built before. To complicate matters the manufacturer, Aeron 2 Company, has not traditionally ...
Evaluation of postponement in the Drug Product supply chain
(Massachusetts Institute of Technology, 2015)
This thesis evaluates the use of postponement in the Drug Product (DP) supply chain at Amgen, which is characterized by highly variable production lead times. The motivation for the use of postponement in the DP supply ...
Augmenting drug process development capacity through applications of lean principles and high throughput technology
(Massachusetts Institute of Technology, 2018)
The long development lead time and high R&D costs for biologics drugs makes it imperative to eliminate delays and inefficiencies. Limited process development capacity can lead to delays in the availability of life-saving ...
Evaluation of automated storage and retrieval in a distribution center
(Massachusetts Institute of Technology, 2020)
In the face of e-commerce growth and rising customer delivery expectations, companies must adapt to meet shorter contract shipping requirements with existing infrastructures. The "Amazon effect", an evolution resulting in ...
Reducing variations in a highly constrained environment in order to increase production capacity
(Massachusetts Institute of Technology, 2020)
Variations and the negatives effects it causes on production capacity and planning are topics of significant interest in the manufacturing communities. This research investigates the hypothesis that, when operating in a ...
Additive manufacturing applications and implementation in aerospace
(Massachusetts Institute of Technology, 2020)
Many aerospace companies are turning to additive manufacturing solutions to stream-line current production processes and open opportunities for on-demand producibility. While many OEMs are drawn to the appeal of the benefits ...
Organizational architecture design and assessment of statistical feasibility for FSDA implementation in an airplane subassembly
(Massachusetts Institute of Technology, 2020)
Boeing is a ubiquitous name and prominent leader in the aerospace industry, maintaining dominance in part by continuously seeking to improve. Boeing is now embracing a charter to become a Global Industrial Champion in ...
Advancing lean implementation for next generation biomanufacturing operations
(Massachusetts Institute of Technology, 2016)
Amgen Singapore Manufacturing (ASM) is a "first of its kind" commercial biomanufacturing site, incorporating myriad innovations including a full scale single-use bioreactor production model. Known internally at Amgen as ...
Quality control improvement in global apparel sourcing
(Massachusetts Institute of Technology, 2016)
This project addressed challenges within the quality management process of one of the operating groups of Li & Fung. The primary goals were improved product quality and reduced quality control costs. The operating group ...