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Carboxyl terminal truncations of the Phage Mu transposase
(Massachusetts Institute of Technology, 1996)
Structural studies on the LINC complex and Fic-1
(Massachusetts Institute of Technology, 2015)
LINC complexes span the nuclear envelope and connect the nucleoskeleton to the cytoskeleton. In 2012, our lab solved the first LINC complex structure, that of SUN domain of human SUN2 bound with KASH1 or KASH2 peptides. ...
Genetic screens in vivo using the CRISPR/Cas9 system
(Massachusetts Institute of Technology, 2017)
An unmet and paramount need in the field of cancer research is to rapidly translate basic biological findings to clinically relevant therapeutics for cancer patients. Recent technological advances have generated many ...
Microbial food web interactions in two Long Island embayments
(Massachusetts Institute of Technology, 1999)
Phytoplankton mortality (herbivory) and bacterivory were examined experimentally in West Neck Bay and Coecles Harbor, Long Island, NY from April through September, 1998. Small algae (<5 [tm diameter) dominated phytoplankton ...
mRNA stability in soma and neurites of cultured neuronal cells
(Massachusetts Institute of Technology, 2017)
Neurons rely on mRNA localization and local protein synthesis in neurites to regulate synaptic plasticity, axonogenesis and neural signaling. The local regulation of mRNA stability in neurites is poorly understood. To ...
CD8⁺ T Cell Response to Influenza Virus
(Massachusetts Institute of Technology, 2005)
The flu is an extremely prevalent and potentially devastating disease, especially dangerous to the very young, the elderly, and to people with compromised immune systems. Influenza has a characteristic course of infection, ...
Analysis of NusA's roles in DNA repair and damage tolerance pathways in Escherichia coli
(Massachusetts Institute of Technology, 2015)
NusA has long known to be a bona fide transcription factor that functions in both termination and antitermination. However, its role in DNA repair and damage tolerance has not been explored until recently. Cohen et al. ...
Estimating phytoplankton growth rates from compositional data
(Massachusetts Institute of Technology, 2008)
I build on the deterministic phytoplankton growth model of Sosik et al. by introducing process error, which simulates real variation in population growth and inaccuracies in the structure of the matrix model. Adding a ...
On the economic optimality of marine reserves when fishing damages habitat
(Massachusetts Institute of Technology, 2010)
In this thesis, I expand a spatially-explicit bioeconomic fishery model to include the negative effects of fishing effort on habitat quality. I consider two forms of effort driven habitat damage: First, fishing effort may ...
Understanding the effects of sex chromosomes and sex hormones on sex differences
(Massachusetts Institute of Technology, 2021)
Biological factors that determine sex and drive sexual differentiation have long been established in humans and other mammalian species. Yet there is a limited understanding of the mechanisms by which these factors give ...