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Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
(Massachusetts Institute of Technology, 2015)
Precise regulation of glutamate homeostasis is critical for normal brain function, as its disruption can impair excitatory transmission and result in neurodegenerative and neuropsychiatric disorders. Critical to maintaining ...
Towards optical connectomics : feasibility of 3D reconstruction of neural morphology using expansion microscopy and in situ molecular barcoding
(Massachusetts Institute of Technology, 2018)
Reconstruction of the 3D morphology of neurons is an essential step towards the analysis and understanding of the structures and functions of neural circuits. Optical microscopy has been a key technology for mapping brain ...
Investigating the influence of LH-projecting BLA neurons upon motivated behavioral responding and appetitive learning
(Massachusetts Institute of Technology, 2015)
To optimize survival, organisms must be able to learn contingencies between external stimuli and rewards and appropriately respond to these associations. Deficits in reward-related learning or reward-seeking are thought ...
Qualitative representation for recognition
(Massachusetts Institute of Technology, 2002)
This thesis describes a representation for objects and scenes that is stable against variations in image intensity caused by illumination changes and tolerant to image degradations such as sensor noise. The representation, ...
The comprehension of main and embedded clauses
(Massachusetts Institute of Technology, 1998)
Lost in translation : on the language-specificity of numerical representation as viewed through a bilingual prism
(Massachusetts Institute of Technology, 1998)
Using size change to predict free-fall trajectories
(Massachusetts Institute of Technology, 1989)
Optimal region coloring by doing image chunking
(Massachusetts Institute of Technology, 1990)
A prefrontal source of visual target enhancement in the macaque area V4
(Massachusetts Institute of Technology, 2017)
The ventral pre-arcuate area (VPA) in the primate prefrontal cortex has recently been found to play an important role in feature-based selection of visual targets in the context of a naturalistic free-gaze visual search ...
Chronic stress-dependent activation of somatostatin neurons in the nucleus accumbens facilitates maladaptive eating behaviors
(Massachusetts Institute of Technology, 2016)
Stressors are known to impact eating behaviors. However, recapitulating the intricate interplay between chronic stress and aberrant human eating patterns in an animal model remains a challenge. Notably, binge eating, a ...