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Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease
(Massachusetts Institute of Technology, 2007)
Vaso-occlusive crises cause most of the morbidity and mortality associated with sickle cell disease. The proximal causes of these occlusive events are not well understood. The risks and consequences of vaso-occlusion however ...
Genomics research and cultivating serendipity in pharmaceutical drug discovery : assessing the competitiveness of R&D productivity between the West and Asia
(Massachusetts Institute of Technology, 2007)
It has been widely reported that pharmaceutical drug discovery innovation began its major decline somewhere in the last decade of the 20th century. After reaching a historical high of 53 new molecular entities (NMEs) in ...
Green fluorescent protein as a mechanical sensor
(Massachusetts Institute of Technology, 2007)
Inquiry into intracellular and cytoskeletal mechanics requires an intracellular mechanical sensor to verify models of sub-cellular structure dynamics. To this end, the green fluorescent protein (GFP) is considered as a ...
Design of a thermal diffusion sensor for noninvasive assessment of skin surface perfusion and endothelial dysfunction
(Massachusetts Institute of Technology, 2008)
The skin microcirculation performs a range of vital functions, such as maintaining nutritional perfusion to the tissues and overall thermoregulation. Not only does impairment to the skin blood supply lead to tissue necrosis ...
Emerin and inherited disease
(Massachusetts Institute of Technology, 2004)
(cont.) nucleus and at the nuclear surface.
DMA : a diabetes disease management system
(Massachusetts Institute of Technology, 2003)
There is a clear and present need to improve the quality of diabetes care. Information technology can be used as a means to that end. In this article, we discuss the design and implementation of a web-based diabetes ...
Organizational design : the integration of pharmaceutical discovery and development
(Massachusetts Institute of Technology, 2004)
The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally ...
Managing revisions of rules and guidelines used in clinical information systems : exploring a hierarchical knowledge representation model
(Massachusetts Institute of Technology, 2004)
One important purpose for creating clinical practice guidelines is to improve quality of care by reducing variations in practice. In the current healthcare environment, guidelines are being advocated as a means to disseminate ...
Characterizing MIT's serial scientist-entrepreneurs in life sciences
(Massachusetts Institute of Technology, 2006)
Since the Bayh-Dole Act of 1980, the commercialization of ideas generated in academia has driven significant startup activity and expansion in the life sciences. This commercial transformation has been shown by others to ...
The pharmaco-economics of combination therapies : a study of the effects of component and market factors on combined therapy price
(Massachusetts Institute of Technology, 2006)
For a growing number of indications, combination therapies are becoming increasingly common due in part to their superior efficacy, as compared to monotherapies. In fact, in the case of infectious diseases such as AIDS and ...