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Using emergent self-organizing maps to identify marine group II archaea genomic fragments from uncharacterized microbial metagenomic sequences
(Massachusetts Institute of Technology, 2010)
The validity and usefulness of clustering marine group II tetranucleotide signatures using emergent self-organizing maps was investigated. Fosmids from the HF200 library were chosen for sequencing based on end-sequence ...
Towards a carbon nanotube antibody sensor
(Massachusetts Institute of Technology, 2012)
This work investigated single-walled carbon nanotube (SWNT)/polymer-protein A complexes for optically reporting antibody concentration via a change in near infrared fluorescent emission after antibody binding. SWNT have ...
Modulation of the response to cisplatin by nitric oxide and reactive oxygen species in melanoma cells
(Massachusetts Institute of Technology, 2013)
Malignant melanoma causes the highest mortality rate in skin cancers. Although cisplatin has proved efficacious in the treatment of various solid tumors, melanoma seems particularly resistant to this chemotherapeutic drug. ...
Cell and nanomaterial-based approaches for diagnosis and chemotherapy of metastatic cancer cells
(Massachusetts Institute of Technology, 2010)
Metastasis is a multistep process during which tumor cells separate from a primary tumor, penetrate the bloodstream, evade host defenses, and colonize distant organs. This final and fatal step in tumor development is the ...
Transcriptional divergence and conservation of human and mouse erythropoiesis
(Massachusetts Institute of Technology, 2014)
Mouse models have been used extensively for decades and have been instrumental in improving our understanding of mammalian erythropoiesis. Nonetheless, there are several examples of variation between human and mouse ...
DNA polymerase beta inhibitor pamoic acid : toxicity to metakaryotic human cancer stem cells (HT-29)
(Massachusetts Institute of Technology, 2016)
Amitotic cells with large, hollow bell-shaped nuclei, or metakaryotic stem cells, are the post-embryonic stem cells of the fetal organs from about the fourth week post conception through physical maturity. These metakaryotic ...
Use Of synthetic solid scaffolds to mechanically support a chondrocyte-seeded peptide hydrogel for articular cartilage repair
(Massachusetts Institute of Technology, 2017)
Post-traumatic osteoarthritis (PTOA) is a subtype of OA associated with cartilage defects caused by traumatic joint injury. Because articular cartilage has a limited innate healing response, due to its avascular, aneural, ...
A computational framework for predicting CHO cell culture performance in bioreactors
(Massachusetts Institute of Technology, 2019)
Breaking the trade-off between speed and productivity is a key milestone across industries. In particular, in the biopharmaceutical industry this trade-off is exacerbated by a highly regulated environment, which hinders ...
Environmental remediation and biofuel production through nanoparticle stimulation of yeast
(Massachusetts Institute of Technology, 2019)
Artificially photosynthetic systems aim to store solar energy and chemically reduce carbon dioxide. These systems have been developed in order to use light to drive processes for carbon fixation into biomass and/or liquid ...
A rapid, flexible and scalable DNA assembly platform for genome engineering and regulated gene expression applications in Plasmodium falciparum
(Massachusetts Institute of Technology, 2015)
Plasmodium falciparum is the deadliest malaria parasite. There is no approved vaccine to prevent this disease, and resistance to available antimalarial drugs is becoming widespread. Identification of parasite genes essential ...