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Now showing items 11-20 of 51
Forecasting resource requirements for drug development long range planning
(Massachusetts Institute of Technology, 2010)
This thesis investigates the use of a task-based Monte Carlo simulation model to forecast headcount and manufacturing capacity requirements for a drug development organization. A pharmaceutical drug development group is ...
Fuel cells : manufacturing strategy for emerging technologies
(Massachusetts Institute of Technology, 2001)
Firms attempting to commercialize emerging technologies face unique challenges. Strategy making is one of the major challenges especially when the industry structure is embryonic. In this environment, it is important not ...
Achieving business and operational excellence in the pharmaceutical industry
(Massachusetts Institute of Technology, 2008)
Historically the pharmaceutical industry has been highly profitable. However, the increasing regulatory requirements, bargaining power of buyers, and drug failures together with the threat of biosimilars and decreasing R&D ...
Reducing complexity In biomanufacturing operations through single-use assemblies
(Massachusetts Institute of Technology, 2012)
Novartis Vaccines and Diagnostics operates a centralized equipment cleaning and preparation suite at a vaccine production facility in Marburg, Germany. The ~100 pieces of multi-use stainless steel, glass, and plastic ...
Operational streamlining in a high-throughput genome sequencing center
(Massachusetts Institute of Technology, 2006)
Advances in medicine rely on accurate data that is rapidly provided. It is therefore critical for the Genome Sequencing platform of the Broad Institute of MIT and Harvard to continually strive to reduce cost, improve ...
Evaluating a continuous improvement initiative using Stakeholder Value Mapping
(Massachusetts Institute of Technology, 2006)
Lean implementations have had a mixed record of success in organizations. One possible explanation for this observation is that lean is built upon a value system that is not always shared by the organizations trying to ...
The conclusion of a biologic's lifecycle : manufacturing sourcing strategies on the eve of follow-on biologics
(Massachusetts Institute of Technology, 2008)
The Amgen Rhode Island facility is dedicated to the production of the biological bulk drug substance (BDS) for Enbrel® (etanercept), which blocks the action of one's immune system, helping to treat immune diseases, such ...
Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
(Massachusetts Institute of Technology, 2009)
Heightened competitive pressures, changes in the regulatory atmosphere, and dropping research and development productivity have been plaguing the pharmaceutical and biotechnology industries. Amgen has felt the effects of ...
Process Analytical Technology in biopharmaceutical manufacturing
(Massachusetts Institute of Technology, 2013)
Process Analytical Technology (PAT) became a well-defined concept within the pharmaceutical industry as a result of a major initiative by the FDA called "Pharmaceutical cGMPs for the 21st Century: A Risk-Based Approach." ...
Application of manufacturing tools in the DNA sequencing process
(Massachusetts Institute of Technology, 1999)