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Now showing items 21-26 of 26
A new mouse model to probe the role of aflatoxin B₁ in liver carcinogenesis
(Massachusetts Institute of Technology, 2010)
One and a half million new cancer cases are reported each year in the United States. Despite this overwhelming burden of disease, current preventative treatments and early detection techniques are inadequate. With cancers, ...
Crystal ball planning for analytics implementation in Singapore
(Massachusetts Institute of Technology, 2014)
Amgen is building a new drug substance manufacturing site in Singapore (ASM). This project identified and mitigated the risks associated with implementing analytical technologies to facilitate the design and implementation ...
Streamlining and standardizing transcriptomic analysis in Amgen process development
(Massachusetts Institute of Technology, 2016)
Building biological understanding of the Chinese Hamster Ovary (CHO) system used to manufacture therapeutic proteins is paramount to efficient CHO bioprocess optimization. This understanding can be built by analyzing and ...
The roles of diet and SirT3 levels in mediating signaling network changes in insulin resistance
(Massachusetts Institute of Technology, 2013)
The goal of my research is to understand the mechanism by which high fat diets mediate insulin sensitivity and the role SirT3 plays in high fat diet-induced insulin resistance. Insulin resistance is defined as the inability ...
A study of inter-individual differences in the DNA damage response
(Massachusetts Institute of Technology, 2012)
Agents that damage our DNA are omnipresent in our environment and inside our cells themselves. Left unrepaired, DNA damage can lead to premature aging, neurodegeneration and cancer. Humans have thus evolved intricate and ...
Development of a microfluidic droplet system for immune Cell multiplexing experimentation
(Massachusetts Institute of Technology, 2019)
An incredibly intricate system composed of many dierent cell types, tissues, and molecules, the immune system is integral to a body's health and well-being. Yet, with the multitude of components present within the system ...