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Now showing items 21-28 of 28
Lean transformation methodology and implementation in biopharmaceutical operations
(Massachusetts Institute of Technology, 2008)
Amgen's Operations division is responsible for the production, release and distribution of commercial and clinical products. Due to industry consolidation, impending competition and revenue impacts, Amgen is facing the ...
Implementation of the new FDA quality by design guidance in pharmaceutical production
(Massachusetts Institute of Technology, 2008)
Due to the highly regulated environment, it is difficult to implement changes to a pharmaceutical process. Even small change request approvals can require months of effort for pharmaceutical companies and regulatory agencies. ...
Critical process parameter determination during production start-up
(Massachusetts Institute of Technology, 2004)
Production start-up data is consistently utilized in a reactive manner during the initial stages of a product's lifecycle. However, if proactive information systems are created before full scale production starts, ramp-up ...
Control and optimization of E. coli picking process for DNA sequencing
(Massachusetts Institute of Technology, 2004)
As part of its responsibility to the National Institutes for Health, the sequencing operation at the Broad Institute strives for cost-effective production. This thesis attempts to reduce variability in the sequencing ...
Genome sequencing technology : improvement of the electrophoretic sequencing process and analysis of the sequencing tool industry
(Massachusetts Institute of Technology, 2005)
A primary bottleneck in DNA-sequencing operations is the capacity of the detection process. Although today's capillary electrophoresis DNA sequencers are faster, more sensitive, and more reliable than their precursors, ...
Process for evaluating options for materials management outsourcing
(Massachusetts Institute of Technology, 2004)
This thesis investigates the issues involved with the outsourcing of the materials management function within aerospace assembly, proposing a process for determining whether all or part of the responsibility should be given ...
Lean supplier relationships in the United Kingdom .
(Massachusetts Institute of Technology, 2004)
The Eastman Kodak Company's Annesley, United Kingdom facility assembles consumer and professional film for distribution to the European, Middle Eastern, African, and Russian (EAMER) region. Under pressure from digital ...
A short-range forecasting and inventory strategy for new product launches
(Massachusetts Institute of Technology, 2005)
Companies like Procter & Gamble that operate on a make-to-stock strategy use forecasts to drive their manufacturing, selling, and buying processes. Because forecasting future demand is not an exact science, inventory ...