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Now showing items 21-30 of 463
Reducing government proposal procurement process complexity
(Massachusetts Institute of Technology, 2014)
US Aerospace Defense Vehicle Manufacturer (UADVM) sells Assembled Complex Equipment to the US Government through multi-year contracts. According to the Truth in Negotiations Act (TINA), such government defense contracts ...
Development of a risk management system for consumables used in biopharmaceutical manufacturing
(Massachusetts Institute of Technology, 2013)
Injectable drugs, like those manufactured by the BioPharmOps group of Novartis Pharmaceuticals AG, must conform to strict guidelines for purity and potency. Recent non-conformances of critical supplied consumables have ...
New approach to drug product process design : leveraging first principles modeling and cross-product process monitoring to improve process design robustness
(Massachusetts Institute of Technology, 2015)
Abstract The vision of the Operations Technology Group at Amgen is to enable a robust pipeline through focused and efficient operations research studies. Process design is traditionally developed by performing experiments, ...
Impact of distributed generation of solar photovoltaic (PV) generation on the Massachusetts transmission system
(Massachusetts Institute of Technology, 2015)
After reaching 250 megawatt direct current (MW dc) of solar photovoltaic (PV) generation installed in Massachusetts (MA) in 2013, four years ahead of schedule, Governor Deval Patrick in May of 2013 announced an increase ...
The Johnson and Johnson journey deploying SmartOps for multi-echelon inventory optimization
(Massachusetts Institute of Technology, 2014)
Multi-echelon inventory technology enables firms to significantly reduce inventory costs. It gives managers the ability to make tradeoffs based on information from the entire supply chain, which results in a more powerful ...
Service based logistics optimization
(Massachusetts Institute of Technology, 2014)
This thesis explores the use of a service based logistics optimization (SBLO) methodology for an inbound reverse logistics network. Currently, Quest Diagnostics solves the vehicle routing problem with time windows (VRPTW) ...
Managing expectations during acquisition of bespoke automation systems
(Massachusetts Institute of Technology, 2016)
A new facility seeks to manufacture inlets for the turbine of the new NDA aircraft. The inlet is a new design and has never been built before. To complicate matters the manufacturer, Aeron 2 Company, has not traditionally ...
Evaluation of postponement in the Drug Product supply chain
(Massachusetts Institute of Technology, 2015)
This thesis evaluates the use of postponement in the Drug Product (DP) supply chain at Amgen, which is characterized by highly variable production lead times. The motivation for the use of postponement in the DP supply ...
Augmenting drug process development capacity through applications of lean principles and high throughput technology
(Massachusetts Institute of Technology, 2018)
The long development lead time and high R&D costs for biologics drugs makes it imperative to eliminate delays and inefficiencies. Limited process development capacity can lead to delays in the availability of life-saving ...
Evaluation of the cost impact of ocean freight for outbound logistics from a supply chain perspective
(Massachusetts Institute of Technology, 2013)
The explosion of the mobile phone industry in 1990s and 2000s has introduced more than a billion mobile phones to consumers in the emerging markets of the world. The mobile phone manufacturing industry's increased competition ...