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Personalized medicine, population genetics and privacy : an empirical study of international gene banks
(Massachusetts Institute of Technology, 2005)
The promise of personalized medicine lies in its potential to fundamentally change healthcare. In the past, pharmaceuticals were prescribed on a "one size fits all" basis-patients with certain disease phenotypes were given ...
Organizational design : the integration of pharmaceutical discovery and development
(Massachusetts Institute of Technology, 2004)
The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally ...
The drug development process : evaluation of PDUFA I/II and investigation into reducing drug development times
(Massachusetts Institute of Technology, 2004)
Published findings report that it takes approximately eight years to bring a novel drug to market at an average cost of $800 million. Over the last ten years, the Food and Drug Administration (FDA) has helped to reduce the ...
Patents and licensing and the commercialization of academic biomedical research
(Massachusetts Institute of Technology, 2004)
This thesis is part of a larger body of research being undertaken by Dr. Fiona Murray and colleagues examining value creation and sharing between and among the three principal players in the commercialization of academic ...
Faculty as founder? : an examination of faculty's role in biomedical start-ups
(Massachusetts Institute of Technology, 2005)
Executive Summary: In this thesis, I examine faculty inventors' involvement in university spin-off firms formed to commercialize their inventions. In particular, I analyze the association between a faculty inventor's various ...
Best care practices in anesthesiology : development and evaluation of an electronic feedback system to improve physician compliance with evidence-based practices
(Massachusetts Institute of Technology, 2007)
Recently, hospitals, regulatory agencies, and insurers have renewed their focus on improving patient care and safety. Outcomes based measures are being utilized and hospitals are being asked to report on whether patients ...
Genomic studies of motif enrichment and conservation in the regulation of gene expression in the brain
(Massachusetts Institute of Technology, 2008)
Several bioinformatic tools will be brought to bear in this thesis to identify specific genomic loci that serve as regulatory gateways of gene expression in brain. These "motifs" are short nucleotide patterns that occur ...
Use of wearable ambulatory monitor in the classification of movement states in Parkinson's disease
(Massachusetts Institute of Technology, 2003)
For Parkinson's patients to function at their best, their medications need to be optimally adjusted to the diurnal variation of symptoms. For this to occur, it is important for the managing clinician to have an accurate ...
Localized customized mortality prediction modeling for patients with acute kidney injury admitted to the intensive care unit
(Massachusetts Institute of Technology, 2009)
Introduction. Models for mortality prediction are traditionally developed from prospective multi-center observational studies involving a heterogeneous group of patients to optimize external validity. We hypothesize that ...
A system for automated lexical mapping
(Massachusetts Institute of Technology, 2005)
Merging of clinical systems and medical databases, or aggregation of information from disparate databases, frequently requires a process where vocabularies are compared and similar concepts are mapped. Using a normalization ...