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Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
(Massachusetts Institute of Technology, 2007)
Background: Investigators have focused on mechano-regulation of upstream signaling and responses at the level of gene transcription, protein translation and post-translational modifications. Intracellular pathways including ...
Towards a microfluidic disease detection deviced based on cellular adhesion differences
(Massachusetts Institute of Technology, 2006)
There is a great need in the fields of biology, medicine, and pharmaceuticals to create high-throughput devices for the detection of specific cell states in a heterogeneous mixture of cells. The desire is to differentiate ...
Modulation of the response to cisplatin by nitric oxide and reactive oxygen species in melanoma cells
(Massachusetts Institute of Technology, 2013)
Malignant melanoma causes the highest mortality rate in skin cancers. Although cisplatin has proved efficacious in the treatment of various solid tumors, melanoma seems particularly resistant to this chemotherapeutic drug. ...
A comparative analysis of age-dependent and birth year cohort-specific cancer mortality data between Japan and the United States
(Massachusetts Institute of Technology, 1999)
A rapid, flexible and scalable DNA assembly platform for genome engineering and regulated gene expression applications in Plasmodium falciparum
(Massachusetts Institute of Technology, 2015)
Plasmodium falciparum is the deadliest malaria parasite. There is no approved vaccine to prevent this disease, and resistance to available antimalarial drugs is becoming widespread. Identification of parasite genes essential ...
Computational modeling and simulation for projectile impact and indentation of biological tissues and polymers
(Massachusetts Institute of Technology, 2017)
Understanding the elastic and viscoelastic responses of biological soft tissues and engineered polymer simulants is of great interest to predicting and preventing penetrative injuries. Detailed understanding of the mechanical ...
Mitigating the effects of ribosome limitations on synthetic circuits via high-gain sRNA-mediated negative feedback
(Massachusetts Institute of Technology, 2015)
Resource limitations in bacterial cells can present significant hurdles that preclude correct synthetic circuit behavior. In a simple circuit with one constitutively expressed protein and one protein whose expression is ...
A computational framework for predicting CHO cell culture performance in bioreactors
(Massachusetts Institute of Technology, 2019)
Breaking the trade-off between speed and productivity is a key milestone across industries. In particular, in the biopharmaceutical industry this trade-off is exacerbated by a highly regulated environment, which hinders ...
Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor
(Massachusetts Institute of Technology, 2004)
One of the major challenges in liver research today lay in the understanding of the complex relationship between liver structure and function. The highly orchestrated events that take place in the liver to maintain homeostasis ...
Crystal ball planning for analytics implementation in Singapore
(Massachusetts Institute of Technology, 2014)
Amgen is building a new drug substance manufacturing site in Singapore (ASM). This project identified and mitigated the risks associated with implementing analytical technologies to facilitate the design and implementation ...